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Antidepressant-Like Effects and Cognitive Enhancement of Coadministration of Chaihu Shugan San and Fluoxetine: Dependent on the BDNF-ERK-CREB Signaling Pathway in the Hippocampus and Frontal Cortex
BACKGROUND: Fluoxetine (FLU) is the first-line and widely used medication for depression; however, FLU treatment is almost ineffective in 30%-40% of patients with depression. In addition, there are some problems in FLU treatment, such as delayed efficacy, large side effects, and poor tolerance. Chai...
Autores principales: | Yan, Lijing, Xu, Xia, He, Zhenyu, Wang, Sheng, Zhao, Linlin, Qiu, Juan, Wang, Dongsheng, Gong, Zhicheng, Qiu, Xinjian, Huang, Huiyong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060874/ https://www.ncbi.nlm.nih.gov/pubmed/32185198 http://dx.doi.org/10.1155/2020/2794263 |
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