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Honeycomb lung‐like structures resulting from clustering of traction bronchiectasis distally in sarcoidosis

Gene expression profiles of patients with progressive sarcoidosis, most of whom had evidence of fibrosis on imaging, have been reported to be similar to those of patients with inflammatory hypersensitivity pneumonitis, while expression profiles in progressive sarcoidosis did not resemble those of id...

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Autores principales: Sawahata, Michiru, Shijubo, Noriharu, Johkoh, Takeshi, Hagiwara, Koichi, Konno, Satoshi, Yamaguchi, Tetsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060894/
https://www.ncbi.nlm.nih.gov/pubmed/32166034
http://dx.doi.org/10.1002/rcr2.539
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author Sawahata, Michiru
Shijubo, Noriharu
Johkoh, Takeshi
Hagiwara, Koichi
Konno, Satoshi
Yamaguchi, Tetsuo
author_facet Sawahata, Michiru
Shijubo, Noriharu
Johkoh, Takeshi
Hagiwara, Koichi
Konno, Satoshi
Yamaguchi, Tetsuo
author_sort Sawahata, Michiru
collection PubMed
description Gene expression profiles of patients with progressive sarcoidosis, most of whom had evidence of fibrosis on imaging, have been reported to be similar to those of patients with inflammatory hypersensitivity pneumonitis, while expression profiles in progressive sarcoidosis did not resemble those of idiopathic pulmonary fibrosis. However, it is not known whether specific parenchymal features discerned on computed tomography (CT) imaging can predict development of fibrosis in pulmonary fibrosis. We herein describe a rare case of pulmonary sarcoidosis with honeycomb lung‐like structures developing as a result of concentration of traction bronchiectasis distally, predominantly in both lower lung fields, which developed through shrinkage of consolidations comprising a “central–peripheral band” detected in a woman in her 60s, with non‐caseating epithelioid granuloma. To our knowledge, this is the first case demonstrating the distinctive morphology and developmental process of honeycomb lung‐like structures in fibrotic pulmonary sarcoidosis.
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spelling pubmed-70608942020-03-12 Honeycomb lung‐like structures resulting from clustering of traction bronchiectasis distally in sarcoidosis Sawahata, Michiru Shijubo, Noriharu Johkoh, Takeshi Hagiwara, Koichi Konno, Satoshi Yamaguchi, Tetsuo Respirol Case Rep Case Reports Gene expression profiles of patients with progressive sarcoidosis, most of whom had evidence of fibrosis on imaging, have been reported to be similar to those of patients with inflammatory hypersensitivity pneumonitis, while expression profiles in progressive sarcoidosis did not resemble those of idiopathic pulmonary fibrosis. However, it is not known whether specific parenchymal features discerned on computed tomography (CT) imaging can predict development of fibrosis in pulmonary fibrosis. We herein describe a rare case of pulmonary sarcoidosis with honeycomb lung‐like structures developing as a result of concentration of traction bronchiectasis distally, predominantly in both lower lung fields, which developed through shrinkage of consolidations comprising a “central–peripheral band” detected in a woman in her 60s, with non‐caseating epithelioid granuloma. To our knowledge, this is the first case demonstrating the distinctive morphology and developmental process of honeycomb lung‐like structures in fibrotic pulmonary sarcoidosis. John Wiley & Sons, Ltd 2020-03-08 /pmc/articles/PMC7060894/ /pubmed/32166034 http://dx.doi.org/10.1002/rcr2.539 Text en © 2020 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Case Reports
Sawahata, Michiru
Shijubo, Noriharu
Johkoh, Takeshi
Hagiwara, Koichi
Konno, Satoshi
Yamaguchi, Tetsuo
Honeycomb lung‐like structures resulting from clustering of traction bronchiectasis distally in sarcoidosis
title Honeycomb lung‐like structures resulting from clustering of traction bronchiectasis distally in sarcoidosis
title_full Honeycomb lung‐like structures resulting from clustering of traction bronchiectasis distally in sarcoidosis
title_fullStr Honeycomb lung‐like structures resulting from clustering of traction bronchiectasis distally in sarcoidosis
title_full_unstemmed Honeycomb lung‐like structures resulting from clustering of traction bronchiectasis distally in sarcoidosis
title_short Honeycomb lung‐like structures resulting from clustering of traction bronchiectasis distally in sarcoidosis
title_sort honeycomb lung‐like structures resulting from clustering of traction bronchiectasis distally in sarcoidosis
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060894/
https://www.ncbi.nlm.nih.gov/pubmed/32166034
http://dx.doi.org/10.1002/rcr2.539
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