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S100A12 in Digestive Diseases and Health: A Scoping Review
Calgranulin proteins are an important class of molecules involved in innate immunity. These members of the S100 class of the EF-hand family of calcium-binding proteins have numerous cellular and antimicrobial functions. One protein in particular, S100A12 (also called EN-RAGE or calgranulin C), is hi...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061133/ https://www.ncbi.nlm.nih.gov/pubmed/32184815 http://dx.doi.org/10.1155/2020/2868373 |
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author | Carvalho, Alexandre Lu, Jacky Francis, Jamisha D. Moore, Rebecca E. Haley, Kathryn P. Doster, Ryan S. Townsend, Steven D. Johnson, Jeremiah G. Damo, Steven M. Gaddy, Jennifer A. |
author_facet | Carvalho, Alexandre Lu, Jacky Francis, Jamisha D. Moore, Rebecca E. Haley, Kathryn P. Doster, Ryan S. Townsend, Steven D. Johnson, Jeremiah G. Damo, Steven M. Gaddy, Jennifer A. |
author_sort | Carvalho, Alexandre |
collection | PubMed |
description | Calgranulin proteins are an important class of molecules involved in innate immunity. These members of the S100 class of the EF-hand family of calcium-binding proteins have numerous cellular and antimicrobial functions. One protein in particular, S100A12 (also called EN-RAGE or calgranulin C), is highly abundant in neutrophils during acute inflammation and has been implicated in immune regulation. Structure-function analyses reveal that S100A12 has the capacity to bind calcium, zinc, and copper, processes that contribute to nutritional immunity against invading microbial pathogens. S100A12 is a ligand for the receptor for advanced glycation end products (RAGE), toll-like receptor 4 (TLR4), and CD36, which promote cellular and immunological pathways to alter inflammation. We conducted a scoping review of the existing literature to define what is known about the association of S100A12 with digestive disease and health. Results suggest that S100A12 is implicated in gastroenteritis, necrotizing enterocolitis, gastritis, gastric cancer, Crohn's disease, irritable bowel syndrome, inflammatory bowel disease, and digestive tract cancers. Together, these results reveal S100A12 is an important molecule broadly associated with the pathogenesis of digestive diseases. |
format | Online Article Text |
id | pubmed-7061133 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-70611332020-03-17 S100A12 in Digestive Diseases and Health: A Scoping Review Carvalho, Alexandre Lu, Jacky Francis, Jamisha D. Moore, Rebecca E. Haley, Kathryn P. Doster, Ryan S. Townsend, Steven D. Johnson, Jeremiah G. Damo, Steven M. Gaddy, Jennifer A. Gastroenterol Res Pract Review Article Calgranulin proteins are an important class of molecules involved in innate immunity. These members of the S100 class of the EF-hand family of calcium-binding proteins have numerous cellular and antimicrobial functions. One protein in particular, S100A12 (also called EN-RAGE or calgranulin C), is highly abundant in neutrophils during acute inflammation and has been implicated in immune regulation. Structure-function analyses reveal that S100A12 has the capacity to bind calcium, zinc, and copper, processes that contribute to nutritional immunity against invading microbial pathogens. S100A12 is a ligand for the receptor for advanced glycation end products (RAGE), toll-like receptor 4 (TLR4), and CD36, which promote cellular and immunological pathways to alter inflammation. We conducted a scoping review of the existing literature to define what is known about the association of S100A12 with digestive disease and health. Results suggest that S100A12 is implicated in gastroenteritis, necrotizing enterocolitis, gastritis, gastric cancer, Crohn's disease, irritable bowel syndrome, inflammatory bowel disease, and digestive tract cancers. Together, these results reveal S100A12 is an important molecule broadly associated with the pathogenesis of digestive diseases. Hindawi 2020-02-26 /pmc/articles/PMC7061133/ /pubmed/32184815 http://dx.doi.org/10.1155/2020/2868373 Text en Copyright © 2020 Alexandre Carvalho et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Carvalho, Alexandre Lu, Jacky Francis, Jamisha D. Moore, Rebecca E. Haley, Kathryn P. Doster, Ryan S. Townsend, Steven D. Johnson, Jeremiah G. Damo, Steven M. Gaddy, Jennifer A. S100A12 in Digestive Diseases and Health: A Scoping Review |
title | S100A12 in Digestive Diseases and Health: A Scoping Review |
title_full | S100A12 in Digestive Diseases and Health: A Scoping Review |
title_fullStr | S100A12 in Digestive Diseases and Health: A Scoping Review |
title_full_unstemmed | S100A12 in Digestive Diseases and Health: A Scoping Review |
title_short | S100A12 in Digestive Diseases and Health: A Scoping Review |
title_sort | s100a12 in digestive diseases and health: a scoping review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061133/ https://www.ncbi.nlm.nih.gov/pubmed/32184815 http://dx.doi.org/10.1155/2020/2868373 |
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