Cargando…

S100A12 in Digestive Diseases and Health: A Scoping Review

Calgranulin proteins are an important class of molecules involved in innate immunity. These members of the S100 class of the EF-hand family of calcium-binding proteins have numerous cellular and antimicrobial functions. One protein in particular, S100A12 (also called EN-RAGE or calgranulin C), is hi...

Descripción completa

Detalles Bibliográficos
Autores principales: Carvalho, Alexandre, Lu, Jacky, Francis, Jamisha D., Moore, Rebecca E., Haley, Kathryn P., Doster, Ryan S., Townsend, Steven D., Johnson, Jeremiah G., Damo, Steven M., Gaddy, Jennifer A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061133/
https://www.ncbi.nlm.nih.gov/pubmed/32184815
http://dx.doi.org/10.1155/2020/2868373
_version_ 1783504350536007680
author Carvalho, Alexandre
Lu, Jacky
Francis, Jamisha D.
Moore, Rebecca E.
Haley, Kathryn P.
Doster, Ryan S.
Townsend, Steven D.
Johnson, Jeremiah G.
Damo, Steven M.
Gaddy, Jennifer A.
author_facet Carvalho, Alexandre
Lu, Jacky
Francis, Jamisha D.
Moore, Rebecca E.
Haley, Kathryn P.
Doster, Ryan S.
Townsend, Steven D.
Johnson, Jeremiah G.
Damo, Steven M.
Gaddy, Jennifer A.
author_sort Carvalho, Alexandre
collection PubMed
description Calgranulin proteins are an important class of molecules involved in innate immunity. These members of the S100 class of the EF-hand family of calcium-binding proteins have numerous cellular and antimicrobial functions. One protein in particular, S100A12 (also called EN-RAGE or calgranulin C), is highly abundant in neutrophils during acute inflammation and has been implicated in immune regulation. Structure-function analyses reveal that S100A12 has the capacity to bind calcium, zinc, and copper, processes that contribute to nutritional immunity against invading microbial pathogens. S100A12 is a ligand for the receptor for advanced glycation end products (RAGE), toll-like receptor 4 (TLR4), and CD36, which promote cellular and immunological pathways to alter inflammation. We conducted a scoping review of the existing literature to define what is known about the association of S100A12 with digestive disease and health. Results suggest that S100A12 is implicated in gastroenteritis, necrotizing enterocolitis, gastritis, gastric cancer, Crohn's disease, irritable bowel syndrome, inflammatory bowel disease, and digestive tract cancers. Together, these results reveal S100A12 is an important molecule broadly associated with the pathogenesis of digestive diseases.
format Online
Article
Text
id pubmed-7061133
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-70611332020-03-17 S100A12 in Digestive Diseases and Health: A Scoping Review Carvalho, Alexandre Lu, Jacky Francis, Jamisha D. Moore, Rebecca E. Haley, Kathryn P. Doster, Ryan S. Townsend, Steven D. Johnson, Jeremiah G. Damo, Steven M. Gaddy, Jennifer A. Gastroenterol Res Pract Review Article Calgranulin proteins are an important class of molecules involved in innate immunity. These members of the S100 class of the EF-hand family of calcium-binding proteins have numerous cellular and antimicrobial functions. One protein in particular, S100A12 (also called EN-RAGE or calgranulin C), is highly abundant in neutrophils during acute inflammation and has been implicated in immune regulation. Structure-function analyses reveal that S100A12 has the capacity to bind calcium, zinc, and copper, processes that contribute to nutritional immunity against invading microbial pathogens. S100A12 is a ligand for the receptor for advanced glycation end products (RAGE), toll-like receptor 4 (TLR4), and CD36, which promote cellular and immunological pathways to alter inflammation. We conducted a scoping review of the existing literature to define what is known about the association of S100A12 with digestive disease and health. Results suggest that S100A12 is implicated in gastroenteritis, necrotizing enterocolitis, gastritis, gastric cancer, Crohn's disease, irritable bowel syndrome, inflammatory bowel disease, and digestive tract cancers. Together, these results reveal S100A12 is an important molecule broadly associated with the pathogenesis of digestive diseases. Hindawi 2020-02-26 /pmc/articles/PMC7061133/ /pubmed/32184815 http://dx.doi.org/10.1155/2020/2868373 Text en Copyright © 2020 Alexandre Carvalho et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Carvalho, Alexandre
Lu, Jacky
Francis, Jamisha D.
Moore, Rebecca E.
Haley, Kathryn P.
Doster, Ryan S.
Townsend, Steven D.
Johnson, Jeremiah G.
Damo, Steven M.
Gaddy, Jennifer A.
S100A12 in Digestive Diseases and Health: A Scoping Review
title S100A12 in Digestive Diseases and Health: A Scoping Review
title_full S100A12 in Digestive Diseases and Health: A Scoping Review
title_fullStr S100A12 in Digestive Diseases and Health: A Scoping Review
title_full_unstemmed S100A12 in Digestive Diseases and Health: A Scoping Review
title_short S100A12 in Digestive Diseases and Health: A Scoping Review
title_sort s100a12 in digestive diseases and health: a scoping review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061133/
https://www.ncbi.nlm.nih.gov/pubmed/32184815
http://dx.doi.org/10.1155/2020/2868373
work_keys_str_mv AT carvalhoalexandre s100a12indigestivediseasesandhealthascopingreview
AT lujacky s100a12indigestivediseasesandhealthascopingreview
AT francisjamishad s100a12indigestivediseasesandhealthascopingreview
AT moorerebeccae s100a12indigestivediseasesandhealthascopingreview
AT haleykathrynp s100a12indigestivediseasesandhealthascopingreview
AT dosterryans s100a12indigestivediseasesandhealthascopingreview
AT townsendstevend s100a12indigestivediseasesandhealthascopingreview
AT johnsonjeremiahg s100a12indigestivediseasesandhealthascopingreview
AT damostevenm s100a12indigestivediseasesandhealthascopingreview
AT gaddyjennifera s100a12indigestivediseasesandhealthascopingreview