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Copeptin as a Biomarker of Atherosclerosis in Type 1 Diabetic Patients

AIM: To evaluate copeptin as an early marker of atherosclerosis in adolescent type 1 diabetics. METHODS: Sixty-two type 1 diabetic patients and 50 healthy volunteers were enrolled in the study. Serum copeptin, glycosylated haemoglobin (HbA1c), lipid profile, oxidised low-density lipoprotein (OxLDL),...

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Autores principales: El Dayem, Soha M. Abd, Battah, Ahmed A., El Bohy, Abo El Magd, Yousef, Rasha Nazih, Talaat, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Republic of Macedonia 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061391/
https://www.ncbi.nlm.nih.gov/pubmed/33318769
http://dx.doi.org/10.3889/oamjms.2019.643
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author El Dayem, Soha M. Abd
Battah, Ahmed A.
El Bohy, Abo El Magd
Yousef, Rasha Nazih
Talaat, Ahmed
author_facet El Dayem, Soha M. Abd
Battah, Ahmed A.
El Bohy, Abo El Magd
Yousef, Rasha Nazih
Talaat, Ahmed
author_sort El Dayem, Soha M. Abd
collection PubMed
description AIM: To evaluate copeptin as an early marker of atherosclerosis in adolescent type 1 diabetics. METHODS: Sixty-two type 1 diabetic patients and 50 healthy volunteers were enrolled in the study. Serum copeptin, glycosylated haemoglobin (HbA1c), lipid profile, oxidised low-density lipoprotein (OxLDL), urinary albumin/creatinine ratio, carotid intimal medial thickness (cIMT), aortic intimal medial thickness (aIMT) and resistivity index were assessed for all participants in the study. RESULTS: HbA1c, albumin/creatinine ratio, lipid profile, OxlDL, copeptin, cIMT and aIMT were significantly higher in diabetic patients. Copeptin was higher in patients with positive cIMT and aIMT. Copeptin correlated with cIMT and aIMT. Stepwise multiple regression analysis found that copeptin correlated with aIMT. ROC curve showed that copeptin had 100 % specificity with aIMT and cIMT and 95.2 and 60,7 sensitivity with aIMT and cIMT respectively. CONCLUSION: Copeptin can be used as a marker for early detection of atherosclerosis of type 1 diabetic patients.
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spelling pubmed-70613912020-12-13 Copeptin as a Biomarker of Atherosclerosis in Type 1 Diabetic Patients El Dayem, Soha M. Abd Battah, Ahmed A. El Bohy, Abo El Magd Yousef, Rasha Nazih Talaat, Ahmed Open Access Maced J Med Sci Clinical Sciences AIM: To evaluate copeptin as an early marker of atherosclerosis in adolescent type 1 diabetics. METHODS: Sixty-two type 1 diabetic patients and 50 healthy volunteers were enrolled in the study. Serum copeptin, glycosylated haemoglobin (HbA1c), lipid profile, oxidised low-density lipoprotein (OxLDL), urinary albumin/creatinine ratio, carotid intimal medial thickness (cIMT), aortic intimal medial thickness (aIMT) and resistivity index were assessed for all participants in the study. RESULTS: HbA1c, albumin/creatinine ratio, lipid profile, OxlDL, copeptin, cIMT and aIMT were significantly higher in diabetic patients. Copeptin was higher in patients with positive cIMT and aIMT. Copeptin correlated with cIMT and aIMT. Stepwise multiple regression analysis found that copeptin correlated with aIMT. ROC curve showed that copeptin had 100 % specificity with aIMT and cIMT and 95.2 and 60,7 sensitivity with aIMT and cIMT respectively. CONCLUSION: Copeptin can be used as a marker for early detection of atherosclerosis of type 1 diabetic patients. Republic of Macedonia 2020-12-13 /pmc/articles/PMC7061391/ /pubmed/33318769 http://dx.doi.org/10.3889/oamjms.2019.643 Text en Copyright: © 2019 Soha M. Abd El Dayem, Ahmed A. Battah, Abo El Magd El Bohy, Rasha Nazih Yousef, Ahmed Talaat. http://creativecommons.org/licenses/CC BY-NC/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0)
spellingShingle Clinical Sciences
El Dayem, Soha M. Abd
Battah, Ahmed A.
El Bohy, Abo El Magd
Yousef, Rasha Nazih
Talaat, Ahmed
Copeptin as a Biomarker of Atherosclerosis in Type 1 Diabetic Patients
title Copeptin as a Biomarker of Atherosclerosis in Type 1 Diabetic Patients
title_full Copeptin as a Biomarker of Atherosclerosis in Type 1 Diabetic Patients
title_fullStr Copeptin as a Biomarker of Atherosclerosis in Type 1 Diabetic Patients
title_full_unstemmed Copeptin as a Biomarker of Atherosclerosis in Type 1 Diabetic Patients
title_short Copeptin as a Biomarker of Atherosclerosis in Type 1 Diabetic Patients
title_sort copeptin as a biomarker of atherosclerosis in type 1 diabetic patients
topic Clinical Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061391/
https://www.ncbi.nlm.nih.gov/pubmed/33318769
http://dx.doi.org/10.3889/oamjms.2019.643
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