Cargando…

Non-clinical safety evaluation of a novel pharmaceutical salt, rosuvastatin ethanolamine, in Wistar rats

Rosuvastatin, a second generation 3-Hydroxy-3-Methyl Glutaryl Coenzyme-A reductase inhibitor, is widely used for the management of hypercholesterolemia. Rosuvastatin ethanolamine, developed by Cadila Healthcare Ltd., is a novel, chemically stable, and pharmaceutically acceptable salt, having better...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vaghasiya, Jigneshkumar, Patel, Satyam, Patel, Sudhir, Kadam, Shekhar, Ranvir, Ramchandra, Patel, Harilal, Sundar, Rajesh, Jain, Mukul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Slovak Toxicology Society SETOX 2019
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061451/ https://www.ncbi.nlm.nih.gov/pubmed/32189982 http://dx.doi.org/10.2478/intox-2019-0002

Ejemplares similares

Evaluation of Adverse Effects of Lisinopril and Rosuvastatin on Hematological and Biochemical Analytes in Wistar Rats
por: Dodiya, Hardik, et al.
Publicado: (2013)

Evaluation of Cardioprotective Effect of 3,5,3′-Tri-iodo-L-thyronine in Isoproterenol-Induced Cardiotoxicity
por: Mishra, Vinay, et al.
Publicado: (2011)

Evaluation of acute physiological and molecular alterations in surgically developed hypothyroid Wistar rats
por: Patel, Maulik, et al.
Publicado: (2013)

Influence of estrous stages on electrocardiography, clinical pathology and ovarian weight of experimental beagle dogs: a retrospective analysis
por: SHAH, Chitrang, et al.
Publicado: (2019)

Saroglitazar suppresses the hepatocellular carcinoma induced by intraperitoneal injection of diethylnitrosamine in C57BL/6 mice fed on choline deficient, l-amino acid- defined, high-fat diet
por: Giri, Suresh R., et al.
Publicado: (2023)

Ethanolamine and Phosphatidylethanolamine: Partners in Health and Disease
por: Patel, Dhaval, et al.
Publicado: (2017)

Dual PPARα/γ agonist saroglitazar improves liver histopathology and biochemistry in experimental NASH models
por: Jain, Mukul R., et al.
Publicado: (2017)

Saroglitazar, a novel PPARα/γ agonist with predominant PPARα activity, shows lipid-lowering and insulin-sensitizing effects in preclinical models
por: Jain, Mukul R, et al.
Publicado: (2015)

Preparation and optimization of microemulsion of rosuvastatin calcium
por: Patel, Zalak B., et al.
Publicado: (2012)

Development and Validation of a Stability-Indicating RP-UPLC Method for Determination of Rosuvastatin and Related Substances in Pharmaceutical Dosage Form
por: Trivedi, Harshal Kanubhai, et al.
Publicado: (2012)

Pharmacokinetics, Safety, and Tolerability of Saroglitazar (ZYH1), a Predominantly PPARα Agonist with Moderate PPARγ Agonist Activity in Healthy Human Subjects
por: Jani, Rajendra H., et al.
Publicado: (2013)

Effect of Vitamin D Analogue on Rosuvastatin-Induced Myopathy in Wistar Rats
por: Chogtu, Bharti, et al.
Publicado: (2020)

Ethanolamine Utilization in Bacteria
por: Kaval, Karan Gautam, et al.
Publicado: (2018)

Ethanolamine utilization in Vibrio alginolyticus
por: Khatri, Neelam, et al.
Publicado: (2012)

Dynamics of the Ethanolamine Glycerophospholipid Remodeling Network
por: Zhang, Lu, et al.
Publicado: (2012)

Comparison of Efficacy and Safety of Fixed Dose Combination of Rosuvastatin and Choline Fenofibrate to Fixed Dose Combination of Rosuvastatin and Fenofibrate in Patients of Mixed Dyslipidemia: A Randomized, Open-label, Multicentre Clinical Trial in Indian Population
por: Barkate, Hanmant, et al.
Publicado: (2018)

Safety Evaluation of Artocarpus altilis as Pharmaceutical Agent in Wistar Rats
por: Sairam, Sudha, et al.
Publicado: (2014)

Hematological and biochemical reference intervals of wild-caught and inhouse adult Indian rhesus macaques (Macaca mulatta)
por: Shah, Niraj A., et al.
Publicado: (2022)

Vaporization and Conversion of Ethanolamines used in Metalworking Operations
por: Kim, Shin-bum, et al.
Publicado: (2010)

Ethanolamine: A novel anti-aging agent
por: Rockenfeller, Patrick, et al.
Publicado: (2015)

Regulation of Phagocytosis in Macrophages by Membrane Ethanolamine Plasmalogens
por: Rubio, Julio M., et al.
Publicado: (2018)

CO(2) Capture with Silylated Ethanolamines and Piperazines
por: Herbig, Marcus, et al.
Publicado: (2019)

Ethanolamine Is a New Anti-Prion Compound
por: Uchiyama, Keiji, et al.
Publicado: (2021)

Cannabidiol's Upregulation of N-acyl Ethanolamines in the Central Nervous System Requires N-acyl Phosphatidyl Ethanolamine-Specific Phospholipase D
por: Leishman, Emma, et al.
Publicado: (2018)

Neuroprotective effects of linagliptin in a rotenone-induced rat model of Parkinson's disease
por: Abhangi, Kinjal V, et al.
Publicado: (2022)

New treatments for Drug Resistant TB: Past imperfect, future bright
por: Udwadia, Zarir F., et al.
Publicado: (2023)

Niclosamide Ethanolamine Salt Alleviates Idiopathic Pulmonary Fibrosis by Modulating the PI3K-mTORC1 Pathway
por: Pei, Xiaolin, et al.
Publicado: (2022)

Protective Effect of Sitagliptin and Rosuvastatin Combination on Vascular Endothelial Dysfunction in Type-2 Diabetes
por: Nade, Vandana S., et al.
Publicado: (2015)

Structural Insight into the Clostridium difficile Ethanolamine Utilisation Microcompartment
por: Pitts, Alison C., et al.
Publicado: (2012)

A Case of Noncardiogenic Pulmonary Edema by Ethanolamine Oleate
por: Lee, Jee Yun, et al.
Publicado: (1994)

Electrosynthesis of polydopamine-ethanolamine films for the development of immunosensing interfaces
por: Almeida, Luís C., et al.
Publicado: (2021)

Discovery in space of ethanolamine, the simplest phospholipid head group
por: Rivilla, Víctor M., et al.
Publicado: (2021)

The biology of lysine acetylation integrates transcriptional programming and metabolism
por: Patel, Jigneshkumar, et al.
Publicado: (2011)

Validated High-Performance Liquid Chromatographic Method for the Estimation of Rosuvastatin Calcium in Bulk and Pharmaceutical Formulations
por: Ashour, Safwan, et al.
Publicado: (2011)

Efficacy and safety of rosuvastatin in the management of dyslipidemia
por: Rubba, Paolo, et al.
Publicado: (2009)

Short- and long-term effects on reproductive parameters of female Wistar rats after exposure to rosuvastatin starting in pre-puberty
por: Barros, Jorge W.F., et al.
Publicado: (2020)

Impact of Vitamin D(3) Deficiency on Phosphatidylcholine-/Ethanolamine, Plasmalogen-, Lyso-Phosphatidylcholine-/Ethanolamine, Carnitine- and Triacyl Glyceride-Homeostasis in Neuroblastoma Cells and Murine Brain
por: Lauer, Anna Andrea, et al.
Publicado: (2021)

Clinical and radiological outcome of arthrocentesis followed by autologous blood injection for treatment of chronic recurrent temporomandibular joint dislocation
por: Patel, Jinesh, et al.
Publicado: (2017)

N-acylation of ethanolamine using lipase: a chemoselective catalyst
por: Kidwai, Mazaahir, et al.
Publicado: (2009)

Ethanolamine: A Signal to Commence a Host-Associated Lifestyle?
por: Garsin, Danielle A.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_vq8dmdsgbt20jkajjjqikgf6ts