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BRCA1 Promoter Methylation Status in 1031 Primary Breast Cancers Predicts Favorable Outcomes Following Chemotherapy

BACKGROUND: Breast Cancer 1 gene (BRCA1) is known to be inactivated in breast tumors by promoter methylation. Tumor cells in patients carrying a germline mutation in BRCA1 are sensitive to cytotoxic drugs that cause DNA double strand breaks. However, very little is known on whether patients with BRC...

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Detalles Bibliográficos
Autores principales:	Stefansson, Olafur A, Hilmarsdottir, Holmfridur, Olafsdottir, Kristrun, Tryggvadottir, Laufey, Sverrisdottir, Asgerdur, Johannsson, Oskar T, Jonasson, Jon G, Eyfjord, Jorunn E, Sigurdsson, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061679/ https://www.ncbi.nlm.nih.gov/pubmed/32175521 http://dx.doi.org/10.1093/jncics/pkz100

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