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Evolution in the Debian GNU/Linux software network: analogies and differences with gene regulatory networks

Biological networks exhibit intricate architectures deemed to be crucial for their functionality. In particular, gene regulatory networks, which play a key role in information processing in the cell, display non-trivial architectural features such as scale-free degree distributions, high modularity...

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Detalles Bibliográficos
Autores principales: Villegas, Pablo, Muñoz, Miguel A., Bonachela, Juan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061711/
http://dx.doi.org/10.1098/rsif.2019.0845
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author Villegas, Pablo
Muñoz, Miguel A.
Bonachela, Juan A.
author_facet Villegas, Pablo
Muñoz, Miguel A.
Bonachela, Juan A.
author_sort Villegas, Pablo
collection PubMed
description Biological networks exhibit intricate architectures deemed to be crucial for their functionality. In particular, gene regulatory networks, which play a key role in information processing in the cell, display non-trivial architectural features such as scale-free degree distributions, high modularity and low average distance between connected genes. Such networks result from complex evolutionary and adaptive processes difficult to track down empirically. On the other hand, there exists detailed information on the developmental (or evolutionary) stages of open-software networks that result from self-organized growth across versions. Here, we study the evolution of the Debian GNU/Linux software network, focusing on the changes of key structural and statistical features over time. Our results show that evolution has led to a network structure in which the out-degree distribution is scale-free and the in-degree distribution is a stretched exponential. In addition, while modularity, directionality of information flow, and average distance between elements grew, vulnerability decreased over time. These features resemble closely those currently shown by gene regulatory networks, suggesting the existence of common adaptive pathways for the architectural design of information-processing networks. Differences in other hierarchical aspects point to system-specific solutions to similar evolutionary challenges.
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spelling pubmed-70617112020-03-26 Evolution in the Debian GNU/Linux software network: analogies and differences with gene regulatory networks Villegas, Pablo Muñoz, Miguel A. Bonachela, Juan A. J R Soc Interface Life Sciences–Physics interface Biological networks exhibit intricate architectures deemed to be crucial for their functionality. In particular, gene regulatory networks, which play a key role in information processing in the cell, display non-trivial architectural features such as scale-free degree distributions, high modularity and low average distance between connected genes. Such networks result from complex evolutionary and adaptive processes difficult to track down empirically. On the other hand, there exists detailed information on the developmental (or evolutionary) stages of open-software networks that result from self-organized growth across versions. Here, we study the evolution of the Debian GNU/Linux software network, focusing on the changes of key structural and statistical features over time. Our results show that evolution has led to a network structure in which the out-degree distribution is scale-free and the in-degree distribution is a stretched exponential. In addition, while modularity, directionality of information flow, and average distance between elements grew, vulnerability decreased over time. These features resemble closely those currently shown by gene regulatory networks, suggesting the existence of common adaptive pathways for the architectural design of information-processing networks. Differences in other hierarchical aspects point to system-specific solutions to similar evolutionary challenges. The Royal Society 2020-02 2020-02-12 /pmc/articles/PMC7061711/ http://dx.doi.org/10.1098/rsif.2019.0845 Text en © 2020 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Life Sciences–Physics interface
Villegas, Pablo
Muñoz, Miguel A.
Bonachela, Juan A.
Evolution in the Debian GNU/Linux software network: analogies and differences with gene regulatory networks
title Evolution in the Debian GNU/Linux software network: analogies and differences with gene regulatory networks
title_full Evolution in the Debian GNU/Linux software network: analogies and differences with gene regulatory networks
title_fullStr Evolution in the Debian GNU/Linux software network: analogies and differences with gene regulatory networks
title_full_unstemmed Evolution in the Debian GNU/Linux software network: analogies and differences with gene regulatory networks
title_short Evolution in the Debian GNU/Linux software network: analogies and differences with gene regulatory networks
title_sort evolution in the debian gnu/linux software network: analogies and differences with gene regulatory networks
topic Life Sciences–Physics interface
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061711/
http://dx.doi.org/10.1098/rsif.2019.0845
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