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Temporospatial Expression of Fgfr1 and 2 During Lung Development, Homeostasis, and Regeneration
Fgfr1 (Fibroblast growth factor receptor 1) and Fgfr2 are dynamically expressed during lung development, homeostasis, and regeneration. Our current analysis indicates that Fgfr2 is expressed in distal epithelial progenitors AT2, AT1, club, and basal cells but not in ciliated or neuroendocrine cells...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061767/ https://www.ncbi.nlm.nih.gov/pubmed/32194398 http://dx.doi.org/10.3389/fphar.2020.00120 |
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author | Yuan, Tingting Klinkhammer, Kylie Lyu, Handeng Gao, Shan Yuan, Jie Hopkins, Seantel Zhang, Jin-San De Langhe, Stijn P. |
author_facet | Yuan, Tingting Klinkhammer, Kylie Lyu, Handeng Gao, Shan Yuan, Jie Hopkins, Seantel Zhang, Jin-San De Langhe, Stijn P. |
author_sort | Yuan, Tingting |
collection | PubMed |
description | Fgfr1 (Fibroblast growth factor receptor 1) and Fgfr2 are dynamically expressed during lung development, homeostasis, and regeneration. Our current analysis indicates that Fgfr2 is expressed in distal epithelial progenitors AT2, AT1, club, and basal cells but not in ciliated or neuroendocrine cells during lung development and homeostasis. However, after injury, Fgfr2 becomes upregulated in neuroendocrine cells and distal club cells. Epithelial Fgfr1 expression is minimal throughout lung development, homeostasis, and regeneration. We further find both Fgfr1 and Fgfr2 strongly expressed in cartilage progenitors and airway smooth muscle cells during lung development, whereas Fgfr1 but not Fgfr2 was expressed in lipofibroblasts and vascular smooth muscle cells. In the adult lung, Fgfr1 and Fgfr2 were mostly downregulated in smooth muscle cells but became upregulated after injury. Fgfr1 remained expressed in mesenchymal alveolar niche cells or lipofibroblasts with lower levels of expression in their descendant (alveolar) myofibroblasts during alveologenesis. |
format | Online Article Text |
id | pubmed-7061767 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70617672020-03-19 Temporospatial Expression of Fgfr1 and 2 During Lung Development, Homeostasis, and Regeneration Yuan, Tingting Klinkhammer, Kylie Lyu, Handeng Gao, Shan Yuan, Jie Hopkins, Seantel Zhang, Jin-San De Langhe, Stijn P. Front Pharmacol Pharmacology Fgfr1 (Fibroblast growth factor receptor 1) and Fgfr2 are dynamically expressed during lung development, homeostasis, and regeneration. Our current analysis indicates that Fgfr2 is expressed in distal epithelial progenitors AT2, AT1, club, and basal cells but not in ciliated or neuroendocrine cells during lung development and homeostasis. However, after injury, Fgfr2 becomes upregulated in neuroendocrine cells and distal club cells. Epithelial Fgfr1 expression is minimal throughout lung development, homeostasis, and regeneration. We further find both Fgfr1 and Fgfr2 strongly expressed in cartilage progenitors and airway smooth muscle cells during lung development, whereas Fgfr1 but not Fgfr2 was expressed in lipofibroblasts and vascular smooth muscle cells. In the adult lung, Fgfr1 and Fgfr2 were mostly downregulated in smooth muscle cells but became upregulated after injury. Fgfr1 remained expressed in mesenchymal alveolar niche cells or lipofibroblasts with lower levels of expression in their descendant (alveolar) myofibroblasts during alveologenesis. Frontiers Media S.A. 2020-03-02 /pmc/articles/PMC7061767/ /pubmed/32194398 http://dx.doi.org/10.3389/fphar.2020.00120 Text en Copyright © 2020 Yuan, Klinkhammer, Lyu, Gao, Yuan, Hopkins, Zhang and De Langhe http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Yuan, Tingting Klinkhammer, Kylie Lyu, Handeng Gao, Shan Yuan, Jie Hopkins, Seantel Zhang, Jin-San De Langhe, Stijn P. Temporospatial Expression of Fgfr1 and 2 During Lung Development, Homeostasis, and Regeneration |
title | Temporospatial Expression of Fgfr1 and 2 During Lung Development, Homeostasis, and Regeneration |
title_full | Temporospatial Expression of Fgfr1 and 2 During Lung Development, Homeostasis, and Regeneration |
title_fullStr | Temporospatial Expression of Fgfr1 and 2 During Lung Development, Homeostasis, and Regeneration |
title_full_unstemmed | Temporospatial Expression of Fgfr1 and 2 During Lung Development, Homeostasis, and Regeneration |
title_short | Temporospatial Expression of Fgfr1 and 2 During Lung Development, Homeostasis, and Regeneration |
title_sort | temporospatial expression of fgfr1 and 2 during lung development, homeostasis, and regeneration |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061767/ https://www.ncbi.nlm.nih.gov/pubmed/32194398 http://dx.doi.org/10.3389/fphar.2020.00120 |
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