Downregulation of RIG-I mediated by ITGB3/c-SRC/STAT3 signaling confers resistance to interferon-α-induced apoptosis in tumor-repopulating cells of melanoma

BACKGROUND: Interferon-α (IFN-α) plays a pivotal role in host antitumor immunity, and the evasion of IFN-α signaling pathway can lead to IFN-α resistance during the treatment of cancer. Although the interplay between IFN-α and tumor cells has been extensively investigated in differentiated tumor cel...

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Detalles Bibliográficos
Autores principales: Li, Yong, Song, Yingqiu, Li, Pindong, Li, Mingxing, Wang, Haizhou, Xu, Tao, Yu, Xiongjie, Yu, Yuandong, Tai, YunYan, Chen, Ping, Cai, Xiaojun, Wang, Xianhe, Xiang, Longchao, Deng, Rui, Zhang, Xiufang, Gao, Liping, Wang, Xuanbin, Liu, Jing, Cao, Fengjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061898/
https://www.ncbi.nlm.nih.gov/pubmed/32152220
http://dx.doi.org/10.1136/jitc-2019-000111

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