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Human transposon insertion profiling by sequencing (TIPseq) to map LINE-1 insertions in single cells
Long interspersed element-1 (LINE-1, L1) sequences, which comprise about 17% of human genome, are the product of one of the most active types of mobile DNAs in modern humans. LINE-1 insertion alleles can cause inherited and de novo genetic diseases, and LINE-1-encoded proteins are highly expressed i...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061987/ https://www.ncbi.nlm.nih.gov/pubmed/32075555 http://dx.doi.org/10.1098/rstb.2019.0335 |