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Revisiting the hypothesis of an energetic barrier to genome complexity between eukaryotes and prokaryotes
The absence of genome complexity in prokaryotes, being the evolutionary precursors to eukaryotic cells comprising all complex life (the prokaryote–eukaryote divide), is a long-standing question in evolutionary biology. A previous study hypothesized that the divide exists because prokaryotic genome s...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062059/ https://www.ncbi.nlm.nih.gov/pubmed/32257343 http://dx.doi.org/10.1098/rsos.191859 |
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author | Chiyomaru, Katsumi Takemoto, Kazuhiro |
author_facet | Chiyomaru, Katsumi Takemoto, Kazuhiro |
author_sort | Chiyomaru, Katsumi |
collection | PubMed |
description | The absence of genome complexity in prokaryotes, being the evolutionary precursors to eukaryotic cells comprising all complex life (the prokaryote–eukaryote divide), is a long-standing question in evolutionary biology. A previous study hypothesized that the divide exists because prokaryotic genome size is constrained by bioenergetics (prokaryotic power per gene or genome being significantly lower than eukaryotic ones). However, this hypothesis was evaluated using a relatively small dataset due to lack of data availability at the time, and is therefore controversial. Accordingly, we constructed a larger dataset of genomes, metabolic rates, cell sizes and ploidy levels to investigate whether an energetic barrier to genome complexity exists between eukaryotes and prokaryotes while statistically controlling for the confounding effects of cell size and phylogenetic signals. Notably, we showed that the differences in bioenergetics between prokaryotes and eukaryotes were less significant than those previously reported. More importantly, we found a limited contribution of power per genome and power per gene to the prokaryote–eukaryote dichotomy. Our findings indicate that the prokaryote–eukaryote divide is hard to explain from the energetic perspective. However, our findings may not entirely discount the traditional hypothesis; in contrast, they indicate the need for more careful examination. |
format | Online Article Text |
id | pubmed-7062059 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-70620592020-03-31 Revisiting the hypothesis of an energetic barrier to genome complexity between eukaryotes and prokaryotes Chiyomaru, Katsumi Takemoto, Kazuhiro R Soc Open Sci Genetics and Genomics The absence of genome complexity in prokaryotes, being the evolutionary precursors to eukaryotic cells comprising all complex life (the prokaryote–eukaryote divide), is a long-standing question in evolutionary biology. A previous study hypothesized that the divide exists because prokaryotic genome size is constrained by bioenergetics (prokaryotic power per gene or genome being significantly lower than eukaryotic ones). However, this hypothesis was evaluated using a relatively small dataset due to lack of data availability at the time, and is therefore controversial. Accordingly, we constructed a larger dataset of genomes, metabolic rates, cell sizes and ploidy levels to investigate whether an energetic barrier to genome complexity exists between eukaryotes and prokaryotes while statistically controlling for the confounding effects of cell size and phylogenetic signals. Notably, we showed that the differences in bioenergetics between prokaryotes and eukaryotes were less significant than those previously reported. More importantly, we found a limited contribution of power per genome and power per gene to the prokaryote–eukaryote dichotomy. Our findings indicate that the prokaryote–eukaryote divide is hard to explain from the energetic perspective. However, our findings may not entirely discount the traditional hypothesis; in contrast, they indicate the need for more careful examination. The Royal Society 2020-02-12 /pmc/articles/PMC7062059/ /pubmed/32257343 http://dx.doi.org/10.1098/rsos.191859 Text en © 2020 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Genetics and Genomics Chiyomaru, Katsumi Takemoto, Kazuhiro Revisiting the hypothesis of an energetic barrier to genome complexity between eukaryotes and prokaryotes |
title | Revisiting the hypothesis of an energetic barrier to genome complexity between eukaryotes and prokaryotes |
title_full | Revisiting the hypothesis of an energetic barrier to genome complexity between eukaryotes and prokaryotes |
title_fullStr | Revisiting the hypothesis of an energetic barrier to genome complexity between eukaryotes and prokaryotes |
title_full_unstemmed | Revisiting the hypothesis of an energetic barrier to genome complexity between eukaryotes and prokaryotes |
title_short | Revisiting the hypothesis of an energetic barrier to genome complexity between eukaryotes and prokaryotes |
title_sort | revisiting the hypothesis of an energetic barrier to genome complexity between eukaryotes and prokaryotes |
topic | Genetics and Genomics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062059/ https://www.ncbi.nlm.nih.gov/pubmed/32257343 http://dx.doi.org/10.1098/rsos.191859 |
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