Metabolite identification, tissue distribution, excretion and preclinical pharmacokinetic studies of ET-26-HCl, a new analogue of etomidate

ET-26-HCl, a novel anaesthetic agent with promising pharmacological properties, lacks extensive studies on pharmacokinetics and disposition in vitro and in vivo. In this study, we investigated the metabolic stability, metabolite production and plasma protein binding (PPB) of ET-26-HCl along with its...

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Detalles Bibliográficos
Autores principales: Yu, Lu, Chen, Xu, Zhang, Wen Sheng, Zheng, Liang, Xu, Wen Wen, Xu, Ming Yu, Jiang, Xue Hua, Wang, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062083/
https://www.ncbi.nlm.nih.gov/pubmed/32257329
http://dx.doi.org/10.1098/rsos.191666

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