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Metformin lowers glucose 6-phosphate in hepatocytes by activation of glycolysis downstream of glucose phosphorylation
The chronic effects of metformin on liver gluconeogenesis involve repression of the G6pc gene, which is regulated by the carbohydrate-response element–binding protein through raised cellular intermediates of glucose metabolism. In this study we determined the candidate mechanisms by which metformin...
Autores principales: | Moonira, Tabassum, Chachra, Shruti S., Ford, Brian E., Marin, Silvia, Alshawi, Ahmed, Adam-Primus, Natasha S., Arden, Catherine, Al-Oanzi, Ziad H., Foretz, Marc, Viollet, Benoit, Cascante, Marta, Agius, Loranne |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062158/ https://www.ncbi.nlm.nih.gov/pubmed/31974165 http://dx.doi.org/10.1074/jbc.RA120.012533 |
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