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HLA-DM catalytically enhances peptide dissociation by sensing peptide–MHC class II interactions throughout the peptide-binding cleft

Human leukocyte antigen-DM (HLA-DM) is an integral component of the major histocompatibility complex class II (MHCII) antigen-processing and -presentation pathway. HLA-DM shapes the immune system by differentially catalyzing peptide exchange on MHCII molecules, thereby editing the peptide-MHCII (pMH...

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Detalles Bibliográficos
Autores principales:	Reyes-Vargas, Eduardo, Barker, Adam P., Zhou, Zemin, He, Xiao, Jensen, Peter E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062162/ https://www.ncbi.nlm.nih.gov/pubmed/31969393 http://dx.doi.org/10.1074/jbc.RA119.010645

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