A lipoprotein lipase–GPI-anchored high-density lipoprotein–binding protein 1 fusion lowers triglycerides in mice: Implications for managing familial chylomicronemia syndrome

Lipoprotein lipase (LPL) is central to triglyceride metabolism. Severely compromised LPL activity causes familial chylomicronemia syndrome (FCS), which is associated with very high plasma triglyceride levels and increased risk of life-threatening pancreatitis. Currently, no approved pharmacological...

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Autores principales: Nimonkar, Amitabh V., Weldon, Stephen, Godbout, Kevin, Panza, Darrell, Hanrahan, Susan, Cubbon, Rose, Xu, Fangmin, Trauger, John W., Gao, Jiaping, Voznesensky, Andrei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062184/
https://www.ncbi.nlm.nih.gov/pubmed/31645434
http://dx.doi.org/10.1074/jbc.RA119.011079

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