A pilot study: VereMTB detection kit for rapid detection of multidrug-resistant mycobcterium tuberculosis in clinical sputum samples

The performance of VereMTB(TM) Detection Kit for detection of multidrug-resistant tuberculosis (MDR-TB) was validated by using 124 sputum samples. Comparing with MGIT culture, the sensitivity and specificity of VereMTB Detection Kit for MTBC detection were 97.0% and 98.3%, respectively. Compared wit...

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Autores principales: Ou, Xichao, Li, Qiang, Su, Dan, Xia, Hui, Wang, Shengfen, Zhao, Bing, Zhao, Yanlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062499/
https://www.ncbi.nlm.nih.gov/pubmed/32150745
http://dx.doi.org/10.1371/journal.pone.0228312
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author Ou, Xichao
Li, Qiang
Su, Dan
Xia, Hui
Wang, Shengfen
Zhao, Bing
Zhao, Yanlin
author_facet Ou, Xichao
Li, Qiang
Su, Dan
Xia, Hui
Wang, Shengfen
Zhao, Bing
Zhao, Yanlin
author_sort Ou, Xichao
collection PubMed
description The performance of VereMTB(TM) Detection Kit for detection of multidrug-resistant tuberculosis (MDR-TB) was validated by using 124 sputum samples. Comparing with MGIT culture, the sensitivity and specificity of VereMTB Detection Kit for MTBC detection were 97.0% and 98.3%, respectively. Compared with MGIT DST, the sensitivity and specificity of VereMTB Detection Kit for RIF resistance detection were 85.7% and 93.9%, respectively, and the sensitivity and specificity of VereMTB Detection Kit for INH resistance detection were 75.0% and 95.7%, respectively. 6 NTM samples were also detected and identified correctly. The VereMTB Detection Kit can detect MDR-TB rapidly and accurately in sputum samples from TB suspects.
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spelling pubmed-70624992020-03-23 A pilot study: VereMTB detection kit for rapid detection of multidrug-resistant mycobcterium tuberculosis in clinical sputum samples Ou, Xichao Li, Qiang Su, Dan Xia, Hui Wang, Shengfen Zhao, Bing Zhao, Yanlin PLoS One Research Article The performance of VereMTB(TM) Detection Kit for detection of multidrug-resistant tuberculosis (MDR-TB) was validated by using 124 sputum samples. Comparing with MGIT culture, the sensitivity and specificity of VereMTB Detection Kit for MTBC detection were 97.0% and 98.3%, respectively. Compared with MGIT DST, the sensitivity and specificity of VereMTB Detection Kit for RIF resistance detection were 85.7% and 93.9%, respectively, and the sensitivity and specificity of VereMTB Detection Kit for INH resistance detection were 75.0% and 95.7%, respectively. 6 NTM samples were also detected and identified correctly. The VereMTB Detection Kit can detect MDR-TB rapidly and accurately in sputum samples from TB suspects. Public Library of Science 2020-03-09 /pmc/articles/PMC7062499/ /pubmed/32150745 http://dx.doi.org/10.1371/journal.pone.0228312 Text en © 2020 Ou et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ou, Xichao
Li, Qiang
Su, Dan
Xia, Hui
Wang, Shengfen
Zhao, Bing
Zhao, Yanlin
A pilot study: VereMTB detection kit for rapid detection of multidrug-resistant mycobcterium tuberculosis in clinical sputum samples
title A pilot study: VereMTB detection kit for rapid detection of multidrug-resistant mycobcterium tuberculosis in clinical sputum samples
title_full A pilot study: VereMTB detection kit for rapid detection of multidrug-resistant mycobcterium tuberculosis in clinical sputum samples
title_fullStr A pilot study: VereMTB detection kit for rapid detection of multidrug-resistant mycobcterium tuberculosis in clinical sputum samples
title_full_unstemmed A pilot study: VereMTB detection kit for rapid detection of multidrug-resistant mycobcterium tuberculosis in clinical sputum samples
title_short A pilot study: VereMTB detection kit for rapid detection of multidrug-resistant mycobcterium tuberculosis in clinical sputum samples
title_sort pilot study: veremtb detection kit for rapid detection of multidrug-resistant mycobcterium tuberculosis in clinical sputum samples
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062499/
https://www.ncbi.nlm.nih.gov/pubmed/32150745
http://dx.doi.org/10.1371/journal.pone.0228312
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