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Simulation model of CA1 pyramidal neurons reveal opposing roles for the Na(+)/Ca(2+) exchange current and Ca(2+)-activated K(+) current during spike-timing dependent synaptic plasticity
Sodium Calcium exchanger (NCX) proteins utilize the electrochemical gradient of Na(+) to generate Ca(2+) efflux (forward mode) or influx (reverse mode). In mammals, there are three unique NCX encoding genes—NCX1, NCX2, and NCX3, that comprise the SLC8A family, and mRNA from all three exchangers is e...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062500/ https://www.ncbi.nlm.nih.gov/pubmed/32150746 http://dx.doi.org/10.1371/journal.pone.0230327 |