An interaction between the III-IV linker and CTD in Na(V)1.5 confers regulation of inactivation by CaM and FHF

Voltage gated sodium channel (VGSC) activation drives the action potential upstroke in cardiac myocytes, skeletal muscles, and neurons. After opening, VGSCs rapidly enter a non-conducting, inactivated state. Impaired inactivation causes persistent inward current and underlies cardiac arrhythmias. VG...

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Detalles Bibliográficos
Autores principales: Gade, Aravind R., Marx, Steven O., Pitt, Geoffrey S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062510/
https://www.ncbi.nlm.nih.gov/pubmed/31865383
http://dx.doi.org/10.1085/jgp.201912434

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062510/
https://www.ncbi.nlm.nih.gov/pubmed/31865383
http://dx.doi.org/10.1085/jgp.201912434

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