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Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia

Targeting commonly altered mechanisms in leukemia can provide additional treatment options. Here, we show that an inducible pathway of myeloid regeneration involving the remodeling of the multipotent progenitor (MPP) compartment downstream of hematopoietic stem cells (HSCs) is commonly hijacked in m...

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Detalles Bibliográficos
Autores principales:	Kang, Yoon-A, Pietras, Eric M., Passegué, Emmanuelle
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062512/ https://www.ncbi.nlm.nih.gov/pubmed/31886826 http://dx.doi.org/10.1084/jem.20190787

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