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Inhibiting both proline biosynthesis and lipogenesis synergistically suppresses tumor growth
Cancer cells often proliferate under hypoxia and reprogram their metabolism. However, how to find targets to effectively block the hypoxia-associated metabolic pathways remains unclear. Here, we developed a tool to conveniently calculate electrons dissipated in metabolic transformations. Based on th...
Autores principales: | Liu, Miao, Wang, Yuanyuan, Yang, Chuanzhen, Ruan, Yuxia, Bai, Changsen, Chu, Qiaoyun, Cui, Yanfen, Chen, Ceshi, Ying, Guoguang, Li, Binghui |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062513/ https://www.ncbi.nlm.nih.gov/pubmed/31961917 http://dx.doi.org/10.1084/jem.20191226 |
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