Emerging roles of IL-34 in health and disease

Macrophages are part of the innate immune system and are present in every organ of the body. They fulfill critical roles in tissue homeostasis and development and are involved in various pathologies. An essential factor for the development, homeostasis, and function of mononuclear phagocytes is the...

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Autores principales: Lelios, Iva, Cansever, Dilay, Utz, Sebastian G., Mildenberger, Wiebke, Stifter, Sebastian A., Greter, Melanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062519/
https://www.ncbi.nlm.nih.gov/pubmed/31940023
http://dx.doi.org/10.1084/jem.20190290
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author Lelios, Iva
Cansever, Dilay
Utz, Sebastian G.
Mildenberger, Wiebke
Stifter, Sebastian A.
Greter, Melanie
author_facet Lelios, Iva
Cansever, Dilay
Utz, Sebastian G.
Mildenberger, Wiebke
Stifter, Sebastian A.
Greter, Melanie
author_sort Lelios, Iva
collection PubMed
description Macrophages are part of the innate immune system and are present in every organ of the body. They fulfill critical roles in tissue homeostasis and development and are involved in various pathologies. An essential factor for the development, homeostasis, and function of mononuclear phagocytes is the colony stimulating factor-1 receptor (CSF-1R), which has two known ligands: CSF-1 and interleukin-34 (IL-34). While CSF-1 has been extensively studied, the biology and functions of IL-34 are only now beginning to be uncovered. In this review, we discuss recent advances of IL-34 biology in health and disease with a specific focus on mononuclear phagocytes.
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spelling pubmed-70625192020-09-02 Emerging roles of IL-34 in health and disease Lelios, Iva Cansever, Dilay Utz, Sebastian G. Mildenberger, Wiebke Stifter, Sebastian A. Greter, Melanie J Exp Med Review Macrophages are part of the innate immune system and are present in every organ of the body. They fulfill critical roles in tissue homeostasis and development and are involved in various pathologies. An essential factor for the development, homeostasis, and function of mononuclear phagocytes is the colony stimulating factor-1 receptor (CSF-1R), which has two known ligands: CSF-1 and interleukin-34 (IL-34). While CSF-1 has been extensively studied, the biology and functions of IL-34 are only now beginning to be uncovered. In this review, we discuss recent advances of IL-34 biology in health and disease with a specific focus on mononuclear phagocytes. Rockefeller University Press 2020-01-15 /pmc/articles/PMC7062519/ /pubmed/31940023 http://dx.doi.org/10.1084/jem.20190290 Text en © 2020 Lelios et al. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Review
Lelios, Iva
Cansever, Dilay
Utz, Sebastian G.
Mildenberger, Wiebke
Stifter, Sebastian A.
Greter, Melanie
Emerging roles of IL-34 in health and disease
title Emerging roles of IL-34 in health and disease
title_full Emerging roles of IL-34 in health and disease
title_fullStr Emerging roles of IL-34 in health and disease
title_full_unstemmed Emerging roles of IL-34 in health and disease
title_short Emerging roles of IL-34 in health and disease
title_sort emerging roles of il-34 in health and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062519/
https://www.ncbi.nlm.nih.gov/pubmed/31940023
http://dx.doi.org/10.1084/jem.20190290
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AT mildenbergerwiebke emergingrolesofil34inhealthanddisease
AT stiftersebastiana emergingrolesofil34inhealthanddisease
AT gretermelanie emergingrolesofil34inhealthanddisease

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