Cargando…
The human fetal thymus generates invariant effector γδ T cells
In the mouse thymus, invariant γδ T cells are generated at well-defined times during development and acquire effector functions before exiting the thymus. However, whether such thymic programming and age-dependent generation of invariant γδ T cells occur in humans is not known. Here we found that, u...
Autores principales: | Tieppo, Paola, Papadopoulou, Maria, Gatti, Deborah, McGovern, Naomi, Chan, Jerry K.Y., Gosselin, Françoise, Goetgeluk, Glenn, Weening, Karin, Ma, Ling, Dauby, Nicolas, Cogan, Alexandra, Donner, Catherine, Ginhoux, Florent, Vandekerckhove, Bart, Vermijlen, David |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062527/ https://www.ncbi.nlm.nih.gov/pubmed/31816633 http://dx.doi.org/10.1084/jem.20190580 |
Ejemplares similares
-
Regulation of γδ T Cell Effector Diversification in the Thymus
por: Parker, Morgan E., et al.
Publicado: (2020) -
Identification of distinct functional thymic programming of fetal and pediatric human γδ thymocytes via single-cell analysis
por: Sanchez Sanchez, Guillem, et al.
Publicado: (2022) -
Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities
por: Van Caeneghem, Yasmine, et al.
Publicado: (2017) -
From thymus to periphery: Molecular basis of effector γδ‐T cell differentiation
por: Fiala, Gina J., et al.
Publicado: (2020) -
The γδ T Lymphocytes of the Perinatal Murine Thymus
por: Zorbas, Michelle I., et al.
Publicado: (1995)