The role of IL-22 in intestinal health and disease

The cytokine interleukin-22 (IL-22) is a critical regulator of epithelial homeostasis. It has been implicated in multiple aspects of epithelial barrier function, including regulation of epithelial cell growth and permeability, production of mucus and antimicrobial proteins (AMPs), and complement pro...

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Autores principales: Keir, Mary E., Yi, Tangsheng, Lu, Timothy T., Ghilardi, Nico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062536/
https://www.ncbi.nlm.nih.gov/pubmed/32997932
http://dx.doi.org/10.1084/jem.20192195
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author Keir, Mary E.
Yi, Tangsheng
Lu, Timothy T.
Ghilardi, Nico
author_facet Keir, Mary E.
Yi, Tangsheng
Lu, Timothy T.
Ghilardi, Nico
author_sort Keir, Mary E.
collection PubMed
description The cytokine interleukin-22 (IL-22) is a critical regulator of epithelial homeostasis. It has been implicated in multiple aspects of epithelial barrier function, including regulation of epithelial cell growth and permeability, production of mucus and antimicrobial proteins (AMPs), and complement production. In this review, we focus specifically on the role of IL-22 in the intestinal epithelium. We summarize recent advances in our understanding of how IL-22 regulates homeostasis and host defense, and we discuss the IL-22 pathway as a therapeutic target in diseases of the intestine, including inflammatory bowel disease (IBD), graft-versus-host disease (GVHD), and cancer.
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spelling pubmed-70625362020-09-02 The role of IL-22 in intestinal health and disease Keir, Mary E. Yi, Tangsheng Lu, Timothy T. Ghilardi, Nico J Exp Med Reviews The cytokine interleukin-22 (IL-22) is a critical regulator of epithelial homeostasis. It has been implicated in multiple aspects of epithelial barrier function, including regulation of epithelial cell growth and permeability, production of mucus and antimicrobial proteins (AMPs), and complement production. In this review, we focus specifically on the role of IL-22 in the intestinal epithelium. We summarize recent advances in our understanding of how IL-22 regulates homeostasis and host defense, and we discuss the IL-22 pathway as a therapeutic target in diseases of the intestine, including inflammatory bowel disease (IBD), graft-versus-host disease (GVHD), and cancer. Rockefeller University Press 2020-02-13 /pmc/articles/PMC7062536/ /pubmed/32997932 http://dx.doi.org/10.1084/jem.20192195 Text en © 2020 Genentech, a member of the Roche Group http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Reviews
Keir, Mary E.
Yi, Tangsheng
Lu, Timothy T.
Ghilardi, Nico
The role of IL-22 in intestinal health and disease
title The role of IL-22 in intestinal health and disease
title_full The role of IL-22 in intestinal health and disease
title_fullStr The role of IL-22 in intestinal health and disease
title_full_unstemmed The role of IL-22 in intestinal health and disease
title_short The role of IL-22 in intestinal health and disease
title_sort role of il-22 in intestinal health and disease
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062536/
https://www.ncbi.nlm.nih.gov/pubmed/32997932
http://dx.doi.org/10.1084/jem.20192195
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