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Liquid-phase mega-electron-volt ultrafast electron diffraction

The conversion of light into usable chemical and mechanical energy is pivotal to several biological and chemical processes, many of which occur in solution. To understand the structure–function relationships mediating these processes, a technique with high spatial and temporal resolutions is require...

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Detalles Bibliográficos
Autores principales: Nunes, J. P. F., Ledbetter, K., Lin, M., Kozina, M., DePonte, D. P., Biasin, E., Centurion, M., Crissman, C. J., Dunning, M., Guillet, S., Jobe, K., Liu, Y., Mo, M., Shen, X., Sublett, R., Weathersby, S., Yoneda, C., Wolf, T. J. A., Yang, J., Cordones, A. A., Wang, X. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Crystallographic Association 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062553/
https://www.ncbi.nlm.nih.gov/pubmed/32161776
http://dx.doi.org/10.1063/1.5144518
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author Nunes, J. P. F.
Ledbetter, K.
Lin, M.
Kozina, M.
DePonte, D. P.
Biasin, E.
Centurion, M.
Crissman, C. J.
Dunning, M.
Guillet, S.
Jobe, K.
Liu, Y.
Mo, M.
Shen, X.
Sublett, R.
Weathersby, S.
Yoneda, C.
Wolf, T. J. A.
Yang, J.
Cordones, A. A.
Wang, X. J.
author_facet Nunes, J. P. F.
Ledbetter, K.
Lin, M.
Kozina, M.
DePonte, D. P.
Biasin, E.
Centurion, M.
Crissman, C. J.
Dunning, M.
Guillet, S.
Jobe, K.
Liu, Y.
Mo, M.
Shen, X.
Sublett, R.
Weathersby, S.
Yoneda, C.
Wolf, T. J. A.
Yang, J.
Cordones, A. A.
Wang, X. J.
author_sort Nunes, J. P. F.
collection PubMed
description The conversion of light into usable chemical and mechanical energy is pivotal to several biological and chemical processes, many of which occur in solution. To understand the structure–function relationships mediating these processes, a technique with high spatial and temporal resolutions is required. Here, we report on the design and commissioning of a liquid-phase mega-electron-volt (MeV) ultrafast electron diffraction instrument for the study of structural dynamics in solution. Limitations posed by the shallow penetration depth of electrons and the resulting information loss due to multiple scattering and the technical challenge of delivering liquids to vacuum were overcome through the use of MeV electrons and a gas-accelerated thin liquid sheet jet. To demonstrate the capabilities of this instrument, the structure of water and its network were resolved up to the [Formula: see text] hydration shell with a spatial resolution of 0.6 Å; preliminary time-resolved experiments demonstrated a temporal resolution of 200 fs.
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spelling pubmed-70625532020-03-11 Liquid-phase mega-electron-volt ultrafast electron diffraction Nunes, J. P. F. Ledbetter, K. Lin, M. Kozina, M. DePonte, D. P. Biasin, E. Centurion, M. Crissman, C. J. Dunning, M. Guillet, S. Jobe, K. Liu, Y. Mo, M. Shen, X. Sublett, R. Weathersby, S. Yoneda, C. Wolf, T. J. A. Yang, J. Cordones, A. A. Wang, X. J. Struct Dyn ARTICLES The conversion of light into usable chemical and mechanical energy is pivotal to several biological and chemical processes, many of which occur in solution. To understand the structure–function relationships mediating these processes, a technique with high spatial and temporal resolutions is required. Here, we report on the design and commissioning of a liquid-phase mega-electron-volt (MeV) ultrafast electron diffraction instrument for the study of structural dynamics in solution. Limitations posed by the shallow penetration depth of electrons and the resulting information loss due to multiple scattering and the technical challenge of delivering liquids to vacuum were overcome through the use of MeV electrons and a gas-accelerated thin liquid sheet jet. To demonstrate the capabilities of this instrument, the structure of water and its network were resolved up to the [Formula: see text] hydration shell with a spatial resolution of 0.6 Å; preliminary time-resolved experiments demonstrated a temporal resolution of 200 fs. American Crystallographic Association 2020-03-09 /pmc/articles/PMC7062553/ /pubmed/32161776 http://dx.doi.org/10.1063/1.5144518 Text en © 2020 Author(s). 2329-7778/2020/7(2)/024301/13 All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle ARTICLES
Nunes, J. P. F.
Ledbetter, K.
Lin, M.
Kozina, M.
DePonte, D. P.
Biasin, E.
Centurion, M.
Crissman, C. J.
Dunning, M.
Guillet, S.
Jobe, K.
Liu, Y.
Mo, M.
Shen, X.
Sublett, R.
Weathersby, S.
Yoneda, C.
Wolf, T. J. A.
Yang, J.
Cordones, A. A.
Wang, X. J.
Liquid-phase mega-electron-volt ultrafast electron diffraction
title Liquid-phase mega-electron-volt ultrafast electron diffraction
title_full Liquid-phase mega-electron-volt ultrafast electron diffraction
title_fullStr Liquid-phase mega-electron-volt ultrafast electron diffraction
title_full_unstemmed Liquid-phase mega-electron-volt ultrafast electron diffraction
title_short Liquid-phase mega-electron-volt ultrafast electron diffraction
title_sort liquid-phase mega-electron-volt ultrafast electron diffraction
topic ARTICLES
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062553/
https://www.ncbi.nlm.nih.gov/pubmed/32161776
http://dx.doi.org/10.1063/1.5144518
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