Butler enables rapid cloud-based analysis of thousands of human genomes

We present Butler, a computational tool that facilitates large-scale genomic analyses on public and academic clouds. Butler includes innovative anomaly detection and self-healing functions that improve the efficiency of data processing and analysis by 43% compared with current approaches. Butler ena...

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Detalles Bibliográficos
Autores principales: Yakneen, Sergei, Waszak, Sebastian M., Gertz, Michael, Korbel, Jan O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2020
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062635/
https://www.ncbi.nlm.nih.gov/pubmed/32024987
http://dx.doi.org/10.1038/s41587-019-0360-3
Descripción
Sumario:We present Butler, a computational tool that facilitates large-scale genomic analyses on public and academic clouds. Butler includes innovative anomaly detection and self-healing functions that improve the efficiency of data processing and analysis by 43% compared with current approaches. Butler enabled processing of a 725-terabyte cancer genome dataset from the Pan-Cancer Analysis of Whole Genomes (PCAWG) project in a time-efficient and uniform manner.

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