Butler enables rapid cloud-based analysis of thousands of human genomes

We present Butler, a computational tool that facilitates large-scale genomic analyses on public and academic clouds. Butler includes innovative anomaly detection and self-healing functions that improve the efficiency of data processing and analysis by 43% compared with current approaches. Butler ena...

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Autores principales: Yakneen, Sergei, Waszak, Sebastian M., Gertz, Michael, Korbel, Jan O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2020
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062635/
https://www.ncbi.nlm.nih.gov/pubmed/32024987
http://dx.doi.org/10.1038/s41587-019-0360-3
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author Yakneen, Sergei
Waszak, Sebastian M.
Gertz, Michael
Korbel, Jan O.
author_facet Yakneen, Sergei
Waszak, Sebastian M.
Gertz, Michael
Korbel, Jan O.
author_sort Yakneen, Sergei
collection PubMed
description We present Butler, a computational tool that facilitates large-scale genomic analyses on public and academic clouds. Butler includes innovative anomaly detection and self-healing functions that improve the efficiency of data processing and analysis by 43% compared with current approaches. Butler enabled processing of a 725-terabyte cancer genome dataset from the Pan-Cancer Analysis of Whole Genomes (PCAWG) project in a time-efficient and uniform manner.
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spelling pubmed-70626352020-03-19 Butler enables rapid cloud-based analysis of thousands of human genomes Yakneen, Sergei Waszak, Sebastian M. Gertz, Michael Korbel, Jan O. Nat Biotechnol Brief Communication We present Butler, a computational tool that facilitates large-scale genomic analyses on public and academic clouds. Butler includes innovative anomaly detection and self-healing functions that improve the efficiency of data processing and analysis by 43% compared with current approaches. Butler enabled processing of a 725-terabyte cancer genome dataset from the Pan-Cancer Analysis of Whole Genomes (PCAWG) project in a time-efficient and uniform manner. Nature Publishing Group US 2020-02-05 2020 /pmc/articles/PMC7062635/ /pubmed/32024987 http://dx.doi.org/10.1038/s41587-019-0360-3 Text en © The Author(s) 2020, corrected publication 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Yakneen, Sergei
Waszak, Sebastian M.
Gertz, Michael
Korbel, Jan O.
Butler enables rapid cloud-based analysis of thousands of human genomes
title Butler enables rapid cloud-based analysis of thousands of human genomes
title_full Butler enables rapid cloud-based analysis of thousands of human genomes
title_fullStr Butler enables rapid cloud-based analysis of thousands of human genomes
title_full_unstemmed Butler enables rapid cloud-based analysis of thousands of human genomes
title_short Butler enables rapid cloud-based analysis of thousands of human genomes
title_sort butler enables rapid cloud-based analysis of thousands of human genomes
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062635/
https://www.ncbi.nlm.nih.gov/pubmed/32024987
http://dx.doi.org/10.1038/s41587-019-0360-3
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