APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice

The ε4 allele of apolipoprotein E (APOE) is the dominant genetic risk factor for late-onset Alzheimer’s disease (AD). However, the reason for the association between APOE4 and AD remains unclear. While much of the research has focused on the ability of the apoE4 protein to increase the aggregation a...

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Detalles Bibliográficos
Autores principales: Area-Gomez, Estela, Larrea, Delfina, Pera, Marta, Agrawal, Rishi R., Guilfoyle, David N., Pirhaji, Leila, Shannon, Kathleen, Arain, Hirra A., Ashok, Archana, Chen, Qiuying, Dillman, Allissa A., Figueroa, Helen Y., Cookson, Mark R., Gross, Steven S., Fraenkel, Ernest, Duff, Karen E., Nuriel, Tal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062695/
https://www.ncbi.nlm.nih.gov/pubmed/32152337
http://dx.doi.org/10.1038/s41598-020-61142-8

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