Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex

Wnt/β-catenin signaling is implicated in many physiological processes, including development, tissue homeostasis, and tissue regeneration. In human cancers, Wnt/β-catenin signaling is highly activated, which has led to the development of various Wnt signaling inhibitors for cancer therapies. Nonethe...

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Detalles Bibliográficos
Autores principales: Jung, Youn-Sang, Park, Jae-Il
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062731/
https://www.ncbi.nlm.nih.gov/pubmed/32037398
http://dx.doi.org/10.1038/s12276-020-0380-6
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author Jung, Youn-Sang
Park, Jae-Il
author_facet Jung, Youn-Sang
Park, Jae-Il
author_sort Jung, Youn-Sang
collection PubMed
description Wnt/β-catenin signaling is implicated in many physiological processes, including development, tissue homeostasis, and tissue regeneration. In human cancers, Wnt/β-catenin signaling is highly activated, which has led to the development of various Wnt signaling inhibitors for cancer therapies. Nonetheless, the blockade of Wnt signaling causes side effects such as impairment of tissue homeostasis and regeneration. Recently, several studies have identified cancer-specific Wnt signaling regulators. In this review, we discuss the Wnt inhibitors currently being used in clinical trials and suggest how additional cancer-specific regulators could be utilized to treat Wnt signaling-associated cancer.
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spelling pubmed-70627312020-03-18 Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex Jung, Youn-Sang Park, Jae-Il Exp Mol Med Review Article Wnt/β-catenin signaling is implicated in many physiological processes, including development, tissue homeostasis, and tissue regeneration. In human cancers, Wnt/β-catenin signaling is highly activated, which has led to the development of various Wnt signaling inhibitors for cancer therapies. Nonetheless, the blockade of Wnt signaling causes side effects such as impairment of tissue homeostasis and regeneration. Recently, several studies have identified cancer-specific Wnt signaling regulators. In this review, we discuss the Wnt inhibitors currently being used in clinical trials and suggest how additional cancer-specific regulators could be utilized to treat Wnt signaling-associated cancer. Nature Publishing Group UK 2020-02-10 /pmc/articles/PMC7062731/ /pubmed/32037398 http://dx.doi.org/10.1038/s12276-020-0380-6 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Jung, Youn-Sang
Park, Jae-Il
Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex
title Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex
title_full Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex
title_fullStr Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex
title_full_unstemmed Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex
title_short Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex
title_sort wnt signaling in cancer: therapeutic targeting of wnt signaling beyond β-catenin and the destruction complex
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062731/
https://www.ncbi.nlm.nih.gov/pubmed/32037398
http://dx.doi.org/10.1038/s12276-020-0380-6
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