Cargando…
Topological dynamics of the 2015 South Korea MERS-CoV spread-on-contact networks
Network analysis to examine infectious contact relations provides an important means to uncover the topologies of individual infectious contact networks. This study aims to investigate the spread of diseases among individuals over contact networks by exploring the 2015 Middle East Respiratory Syndro...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062829/ https://www.ncbi.nlm.nih.gov/pubmed/32152361 http://dx.doi.org/10.1038/s41598-020-61133-9 |
_version_ | 1783504588501942272 |
---|---|
author | Yang, Chang Hoon Jung, Hyejin |
author_facet | Yang, Chang Hoon Jung, Hyejin |
author_sort | Yang, Chang Hoon |
collection | PubMed |
description | Network analysis to examine infectious contact relations provides an important means to uncover the topologies of individual infectious contact networks. This study aims to investigate the spread of diseases among individuals over contact networks by exploring the 2015 Middle East Respiratory Syndrome (MERS) outbreak in Korea. We present several distinct features of MERS transmission by employing a comprehensive approach in network research to examine both the traced relationship matrix of infected individuals and their bipartite transmission routes among healthcare facilities visited for treatment. The results indicate that a few super-spreaders were more likely to hold certain structural advantages by linking to an exceptional number of other individuals, causing several ongoing transmission events in neighbourhoods without the aid of any intermediary. Thus, the infectious contact network exhibited small-world dynamics characterised by locally clustered contacts exposed to transmission paths via short path lengths. In addition, nosocomial infection analysis shows the pattern of a common-source outbreak followed by secondary person-to-person transmission of the disease. Based on the results, we suggest policy implications related to the redesign of prevention and control strategies against the spread of epidemics. |
format | Online Article Text |
id | pubmed-7062829 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-70628292020-03-18 Topological dynamics of the 2015 South Korea MERS-CoV spread-on-contact networks Yang, Chang Hoon Jung, Hyejin Sci Rep Article Network analysis to examine infectious contact relations provides an important means to uncover the topologies of individual infectious contact networks. This study aims to investigate the spread of diseases among individuals over contact networks by exploring the 2015 Middle East Respiratory Syndrome (MERS) outbreak in Korea. We present several distinct features of MERS transmission by employing a comprehensive approach in network research to examine both the traced relationship matrix of infected individuals and their bipartite transmission routes among healthcare facilities visited for treatment. The results indicate that a few super-spreaders were more likely to hold certain structural advantages by linking to an exceptional number of other individuals, causing several ongoing transmission events in neighbourhoods without the aid of any intermediary. Thus, the infectious contact network exhibited small-world dynamics characterised by locally clustered contacts exposed to transmission paths via short path lengths. In addition, nosocomial infection analysis shows the pattern of a common-source outbreak followed by secondary person-to-person transmission of the disease. Based on the results, we suggest policy implications related to the redesign of prevention and control strategies against the spread of epidemics. Nature Publishing Group UK 2020-03-09 /pmc/articles/PMC7062829/ /pubmed/32152361 http://dx.doi.org/10.1038/s41598-020-61133-9 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Yang, Chang Hoon Jung, Hyejin Topological dynamics of the 2015 South Korea MERS-CoV spread-on-contact networks |
title | Topological dynamics of the 2015 South Korea MERS-CoV spread-on-contact networks |
title_full | Topological dynamics of the 2015 South Korea MERS-CoV spread-on-contact networks |
title_fullStr | Topological dynamics of the 2015 South Korea MERS-CoV spread-on-contact networks |
title_full_unstemmed | Topological dynamics of the 2015 South Korea MERS-CoV spread-on-contact networks |
title_short | Topological dynamics of the 2015 South Korea MERS-CoV spread-on-contact networks |
title_sort | topological dynamics of the 2015 south korea mers-cov spread-on-contact networks |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062829/ https://www.ncbi.nlm.nih.gov/pubmed/32152361 http://dx.doi.org/10.1038/s41598-020-61133-9 |
work_keys_str_mv | AT yangchanghoon topologicaldynamicsofthe2015southkoreamerscovspreadoncontactnetworks AT junghyejin topologicaldynamicsofthe2015southkoreamerscovspreadoncontactnetworks |