Hypoxia sensing by hepatic stellate cells leads to VEGF-dependent angiogenesis and may contribute to accelerated liver regeneration

Portal vein ligation (PVL) induces liver growth prior to resection. Associating liver partition and portal vein ligation (PVL plus transection=ALPPS) or the addition of the prolyl-hydroxylase inhibitor dimethyloxalylglycine (DMOG) to PVL both accelerate growth via stabilization of HIF-α subunits. Th...

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Detalles Bibliográficos
Autores principales: Dirscherl, Konstantin, Schläpfer, Martin, Roth Z’graggen, Birgit, Wenger, Roland H, Booy, Christa, Flury-Frei, Renata, Fatzer, Rita, Aloman, Costica, Bartosch, Birke, Parent, Romain, Kurtcuoglu, Vartan, de Zélicourt, Diane, Spahn, Donat R., Beck Schimmer, Beatrice, Schadde, Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062856/
https://www.ncbi.nlm.nih.gov/pubmed/32152325
http://dx.doi.org/10.1038/s41598-020-60709-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062856/
https://www.ncbi.nlm.nih.gov/pubmed/32152325
http://dx.doi.org/10.1038/s41598-020-60709-9

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