Cargando…

The Value of (99m)Tc-Methylene Diphosphonate Single-Photon Emission Computed Tomography/Computed Tomography in Detecting Atraumatic Costal Cartilage Fracture in Malignant Tumor Patients

Objectives: To assess the clinical significance and single-photon emission computed tomography/computed tomography (SPECT/CT) features of atraumatic costal cartilage fracture (CCF) in patients with malignant tumors. Methods: This was a retrospective review of 38 tumor patients with atraumatic CCF re...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Wei, Zhang, Linqi, Li, Wen, Zhang, Rusen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062865/
https://www.ncbi.nlm.nih.gov/pubmed/32195167
http://dx.doi.org/10.3389/fonc.2020.00138
_version_ 1783504596884258816
author Li, Wei
Zhang, Linqi
Li, Wen
Zhang, Rusen
author_facet Li, Wei
Zhang, Linqi
Li, Wen
Zhang, Rusen
author_sort Li, Wei
collection PubMed
description Objectives: To assess the clinical significance and single-photon emission computed tomography/computed tomography (SPECT/CT) features of atraumatic costal cartilage fracture (CCF) in patients with malignant tumors. Methods: This was a retrospective review of 38 tumor patients with atraumatic CCF referred to SPECT/CT, who were served as the study group (SG). The features of SPECT/CT of atraumatic CCF were assessed. Another 100 tumor patients who underwent chest SPECT/CT and did not have CCF were randomly selected as the control group (CG). In all patients (SG + CG), the diagnostic powers in the detection of atraumatic CCF were computed among CT, SPECT, and SPECT/CT. The final diagnosis was based on pathological findings and radiologic follow-up of at least 1 year. Results: On SPECT/CT images of atraumatic CCF in the SG, fracture lines, irregular calcification, deformation, and swelling were, respectively, noted in 26.3, 47.4, 34.2, and 18.4% of lesions; low, moderate, and high uptake were, respectively, noted in 13.2, 52.6, and 34.2% of lesions. In all patients (SG + CG), the diagnostic powers in the detection of atraumatic CCF of CT, SPECT, and SPECT/CT were as follows: sensitivity 63.2, 100.0, and 92.1%; specificity 86.0, 81.0, and 94.0%; negative predictive value 86.0, 100.0, and 96.9%; positive predictive value 63.1, 66.7, and 85.4%; and area under the curve value 0.746, 0.905, and 0.931. Conclusions: Atraumatic CCF has certain characteristic appearances on SPECT/CT. It should be enrolled in the differential diagnoses when costal cartilages of patients with malignant tumors show abnormal elevated (99m)Tc-MDP uptake on scintigraphy. Single-photon emission computed tomography/CT has excellent diagnostic power in detecting atraumatic CCF.
format Online
Article
Text
id pubmed-7062865
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-70628652020-03-19 The Value of (99m)Tc-Methylene Diphosphonate Single-Photon Emission Computed Tomography/Computed Tomography in Detecting Atraumatic Costal Cartilage Fracture in Malignant Tumor Patients Li, Wei Zhang, Linqi Li, Wen Zhang, Rusen Front Oncol Oncology Objectives: To assess the clinical significance and single-photon emission computed tomography/computed tomography (SPECT/CT) features of atraumatic costal cartilage fracture (CCF) in patients with malignant tumors. Methods: This was a retrospective review of 38 tumor patients with atraumatic CCF referred to SPECT/CT, who were served as the study group (SG). The features of SPECT/CT of atraumatic CCF were assessed. Another 100 tumor patients who underwent chest SPECT/CT and did not have CCF were randomly selected as the control group (CG). In all patients (SG + CG), the diagnostic powers in the detection of atraumatic CCF were computed among CT, SPECT, and SPECT/CT. The final diagnosis was based on pathological findings and radiologic follow-up of at least 1 year. Results: On SPECT/CT images of atraumatic CCF in the SG, fracture lines, irregular calcification, deformation, and swelling were, respectively, noted in 26.3, 47.4, 34.2, and 18.4% of lesions; low, moderate, and high uptake were, respectively, noted in 13.2, 52.6, and 34.2% of lesions. In all patients (SG + CG), the diagnostic powers in the detection of atraumatic CCF of CT, SPECT, and SPECT/CT were as follows: sensitivity 63.2, 100.0, and 92.1%; specificity 86.0, 81.0, and 94.0%; negative predictive value 86.0, 100.0, and 96.9%; positive predictive value 63.1, 66.7, and 85.4%; and area under the curve value 0.746, 0.905, and 0.931. Conclusions: Atraumatic CCF has certain characteristic appearances on SPECT/CT. It should be enrolled in the differential diagnoses when costal cartilages of patients with malignant tumors show abnormal elevated (99m)Tc-MDP uptake on scintigraphy. Single-photon emission computed tomography/CT has excellent diagnostic power in detecting atraumatic CCF. Frontiers Media S.A. 2020-03-03 /pmc/articles/PMC7062865/ /pubmed/32195167 http://dx.doi.org/10.3389/fonc.2020.00138 Text en Copyright © 2020 Li, Zhang, Li and Zhang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Li, Wei
Zhang, Linqi
Li, Wen
Zhang, Rusen
The Value of (99m)Tc-Methylene Diphosphonate Single-Photon Emission Computed Tomography/Computed Tomography in Detecting Atraumatic Costal Cartilage Fracture in Malignant Tumor Patients
title The Value of (99m)Tc-Methylene Diphosphonate Single-Photon Emission Computed Tomography/Computed Tomography in Detecting Atraumatic Costal Cartilage Fracture in Malignant Tumor Patients
title_full The Value of (99m)Tc-Methylene Diphosphonate Single-Photon Emission Computed Tomography/Computed Tomography in Detecting Atraumatic Costal Cartilage Fracture in Malignant Tumor Patients
title_fullStr The Value of (99m)Tc-Methylene Diphosphonate Single-Photon Emission Computed Tomography/Computed Tomography in Detecting Atraumatic Costal Cartilage Fracture in Malignant Tumor Patients
title_full_unstemmed The Value of (99m)Tc-Methylene Diphosphonate Single-Photon Emission Computed Tomography/Computed Tomography in Detecting Atraumatic Costal Cartilage Fracture in Malignant Tumor Patients
title_short The Value of (99m)Tc-Methylene Diphosphonate Single-Photon Emission Computed Tomography/Computed Tomography in Detecting Atraumatic Costal Cartilage Fracture in Malignant Tumor Patients
title_sort value of (99m)tc-methylene diphosphonate single-photon emission computed tomography/computed tomography in detecting atraumatic costal cartilage fracture in malignant tumor patients
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062865/
https://www.ncbi.nlm.nih.gov/pubmed/32195167
http://dx.doi.org/10.3389/fonc.2020.00138
work_keys_str_mv AT liwei thevalueof99mtcmethylenediphosphonatesinglephotonemissioncomputedtomographycomputedtomographyindetectingatraumaticcostalcartilagefractureinmalignanttumorpatients
AT zhanglinqi thevalueof99mtcmethylenediphosphonatesinglephotonemissioncomputedtomographycomputedtomographyindetectingatraumaticcostalcartilagefractureinmalignanttumorpatients
AT liwen thevalueof99mtcmethylenediphosphonatesinglephotonemissioncomputedtomographycomputedtomographyindetectingatraumaticcostalcartilagefractureinmalignanttumorpatients
AT zhangrusen thevalueof99mtcmethylenediphosphonatesinglephotonemissioncomputedtomographycomputedtomographyindetectingatraumaticcostalcartilagefractureinmalignanttumorpatients
AT liwei valueof99mtcmethylenediphosphonatesinglephotonemissioncomputedtomographycomputedtomographyindetectingatraumaticcostalcartilagefractureinmalignanttumorpatients
AT zhanglinqi valueof99mtcmethylenediphosphonatesinglephotonemissioncomputedtomographycomputedtomographyindetectingatraumaticcostalcartilagefractureinmalignanttumorpatients
AT liwen valueof99mtcmethylenediphosphonatesinglephotonemissioncomputedtomographycomputedtomographyindetectingatraumaticcostalcartilagefractureinmalignanttumorpatients
AT zhangrusen valueof99mtcmethylenediphosphonatesinglephotonemissioncomputedtomographycomputedtomographyindetectingatraumaticcostalcartilagefractureinmalignanttumorpatients