Cargando…

Pleural aspergillosis in a patient with recurrent spontaneous pneumothorax: The challenge of an optimal therapeutic approach

Pleural aspergillosis (PA) is a rare but potentially fatal disease. Most cases are secondary to bronchopleural fistulae or pleural intervention and can occur in the absence of immunosuppression. We report a case of PA in a young patient after pleurodesis for recurrent pneumothorax. Clinical resoluti...

Descripción completa

Detalles Bibliográficos
Autores principales: Abreu, Isabel, Guedes, Mariana, Duro, Raquel, Lopes, Sara, Maciel, João, Santos, Lurdes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063088/
https://www.ncbi.nlm.nih.gov/pubmed/32181124
http://dx.doi.org/10.1016/j.mmcr.2020.02.004
_version_ 1783504642874802176
author Abreu, Isabel
Guedes, Mariana
Duro, Raquel
Lopes, Sara
Maciel, João
Santos, Lurdes
author_facet Abreu, Isabel
Guedes, Mariana
Duro, Raquel
Lopes, Sara
Maciel, João
Santos, Lurdes
author_sort Abreu, Isabel
collection PubMed
description Pleural aspergillosis (PA) is a rare but potentially fatal disease. Most cases are secondary to bronchopleural fistulae or pleural intervention and can occur in the absence of immunosuppression. We report a case of PA in a young patient after pleurodesis for recurrent pneumothorax. Clinical resolution was achieved with systemic and local antifungal therapy combined with surgical debridement. Hepatotoxicity led to a switch from voriconazole to isavuconazole, with a successful outcome.
format Online
Article
Text
id pubmed-7063088
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-70630882020-03-16 Pleural aspergillosis in a patient with recurrent spontaneous pneumothorax: The challenge of an optimal therapeutic approach Abreu, Isabel Guedes, Mariana Duro, Raquel Lopes, Sara Maciel, João Santos, Lurdes Med Mycol Case Rep Case Report Pleural aspergillosis (PA) is a rare but potentially fatal disease. Most cases are secondary to bronchopleural fistulae or pleural intervention and can occur in the absence of immunosuppression. We report a case of PA in a young patient after pleurodesis for recurrent pneumothorax. Clinical resolution was achieved with systemic and local antifungal therapy combined with surgical debridement. Hepatotoxicity led to a switch from voriconazole to isavuconazole, with a successful outcome. Elsevier 2020-02-24 /pmc/articles/PMC7063088/ /pubmed/32181124 http://dx.doi.org/10.1016/j.mmcr.2020.02.004 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Abreu, Isabel
Guedes, Mariana
Duro, Raquel
Lopes, Sara
Maciel, João
Santos, Lurdes
Pleural aspergillosis in a patient with recurrent spontaneous pneumothorax: The challenge of an optimal therapeutic approach
title Pleural aspergillosis in a patient with recurrent spontaneous pneumothorax: The challenge of an optimal therapeutic approach
title_full Pleural aspergillosis in a patient with recurrent spontaneous pneumothorax: The challenge of an optimal therapeutic approach
title_fullStr Pleural aspergillosis in a patient with recurrent spontaneous pneumothorax: The challenge of an optimal therapeutic approach
title_full_unstemmed Pleural aspergillosis in a patient with recurrent spontaneous pneumothorax: The challenge of an optimal therapeutic approach
title_short Pleural aspergillosis in a patient with recurrent spontaneous pneumothorax: The challenge of an optimal therapeutic approach
title_sort pleural aspergillosis in a patient with recurrent spontaneous pneumothorax: the challenge of an optimal therapeutic approach
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063088/
https://www.ncbi.nlm.nih.gov/pubmed/32181124
http://dx.doi.org/10.1016/j.mmcr.2020.02.004
work_keys_str_mv AT abreuisabel pleuralaspergillosisinapatientwithrecurrentspontaneouspneumothoraxthechallengeofanoptimaltherapeuticapproach
AT guedesmariana pleuralaspergillosisinapatientwithrecurrentspontaneouspneumothoraxthechallengeofanoptimaltherapeuticapproach
AT duroraquel pleuralaspergillosisinapatientwithrecurrentspontaneouspneumothoraxthechallengeofanoptimaltherapeuticapproach
AT lopessara pleuralaspergillosisinapatientwithrecurrentspontaneouspneumothoraxthechallengeofanoptimaltherapeuticapproach
AT macieljoao pleuralaspergillosisinapatientwithrecurrentspontaneouspneumothoraxthechallengeofanoptimaltherapeuticapproach
AT santoslurdes pleuralaspergillosisinapatientwithrecurrentspontaneouspneumothoraxthechallengeofanoptimaltherapeuticapproach