2-Hydroxyglutarate Metabolism Is Altered in an in vivo Model of LPS Induced Endotoxemia

The metabolic response to endotoxemia closely mimics those seen in sepsis. Here, we show that the urinary excretion of the metabolite 2-hydroxyglutarate (2HG) is dramatically suppressed following lipopolysaccharide (LPS) administration in vivo, and in human septic patients. We further show that enha...

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Detalles Bibliográficos
Autores principales: Fitzpatrick, Susan F., Lambden, Simon, Macias, David, Puthucheary, Zudin, Pietsch, Sandra, Mendil, Lee, McPhail, Mark J. W., Johnson, Randall S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063103/
https://www.ncbi.nlm.nih.gov/pubmed/32194434
http://dx.doi.org/10.3389/fphys.2020.00147

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