The Protective Effects and Mechanisms of Apelin/APJ System on Ischemic Stroke: A Promising Therapeutic Target

The orphan receptor APJ and its endogenous ligand apelin, which are expressed in the brain, are the major components of the apelin/APJ system. Growing evidence shows that the apelin/APJ system plays a vital role in the pathophysiology of cerebral ischemic injury. Targeting the apelin/APJ system may...

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Autores principales: Tian, Yanjun, Chen, Ruijiao, Jiang, Yunlu, Bai, Bo, Yang, Tongju, Liu, Haiqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063119/
https://www.ncbi.nlm.nih.gov/pubmed/32194492
http://dx.doi.org/10.3389/fneur.2020.00075
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author Tian, Yanjun
Chen, Ruijiao
Jiang, Yunlu
Bai, Bo
Yang, Tongju
Liu, Haiqing
author_facet Tian, Yanjun
Chen, Ruijiao
Jiang, Yunlu
Bai, Bo
Yang, Tongju
Liu, Haiqing
author_sort Tian, Yanjun
collection PubMed
description The orphan receptor APJ and its endogenous ligand apelin, which are expressed in the brain, are the major components of the apelin/APJ system. Growing evidence shows that the apelin/APJ system plays a vital role in the pathophysiology of cerebral ischemic injury. Targeting the apelin/APJ system may have protective effects on cerebral ischemic injury. In this review, we sum up the latest research progress relating to the actions and therapeutic potential of the apelin/APJ system in ischemic stroke. An in-depth knowledge of the pathophysiological effects of the apelin/APJ system and the underlying mechanisms will help to develop novel therapeutic interventions for ischemic stroke.
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spelling pubmed-70631192020-03-19 The Protective Effects and Mechanisms of Apelin/APJ System on Ischemic Stroke: A Promising Therapeutic Target Tian, Yanjun Chen, Ruijiao Jiang, Yunlu Bai, Bo Yang, Tongju Liu, Haiqing Front Neurol Neurology The orphan receptor APJ and its endogenous ligand apelin, which are expressed in the brain, are the major components of the apelin/APJ system. Growing evidence shows that the apelin/APJ system plays a vital role in the pathophysiology of cerebral ischemic injury. Targeting the apelin/APJ system may have protective effects on cerebral ischemic injury. In this review, we sum up the latest research progress relating to the actions and therapeutic potential of the apelin/APJ system in ischemic stroke. An in-depth knowledge of the pathophysiological effects of the apelin/APJ system and the underlying mechanisms will help to develop novel therapeutic interventions for ischemic stroke. Frontiers Media S.A. 2020-03-03 /pmc/articles/PMC7063119/ /pubmed/32194492 http://dx.doi.org/10.3389/fneur.2020.00075 Text en Copyright © 2020 Tian, Chen, Jiang, Bai, Yang and Liu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Tian, Yanjun
Chen, Ruijiao
Jiang, Yunlu
Bai, Bo
Yang, Tongju
Liu, Haiqing
The Protective Effects and Mechanisms of Apelin/APJ System on Ischemic Stroke: A Promising Therapeutic Target
title The Protective Effects and Mechanisms of Apelin/APJ System on Ischemic Stroke: A Promising Therapeutic Target
title_full The Protective Effects and Mechanisms of Apelin/APJ System on Ischemic Stroke: A Promising Therapeutic Target
title_fullStr The Protective Effects and Mechanisms of Apelin/APJ System on Ischemic Stroke: A Promising Therapeutic Target
title_full_unstemmed The Protective Effects and Mechanisms of Apelin/APJ System on Ischemic Stroke: A Promising Therapeutic Target
title_short The Protective Effects and Mechanisms of Apelin/APJ System on Ischemic Stroke: A Promising Therapeutic Target
title_sort protective effects and mechanisms of apelin/apj system on ischemic stroke: a promising therapeutic target
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063119/
https://www.ncbi.nlm.nih.gov/pubmed/32194492
http://dx.doi.org/10.3389/fneur.2020.00075
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