Ability of FFR-CT to detect the absence of hemodynamically significant lesions in patients with high-risk NSTE-ACS admitted in the emergency department with chest pain, study design and rationale

BACKGROUND: In the era of High-sensitive troponin (hs-Tn), up to 50% of patients with a mild increase of hs-Tn will finally have a normal invasive coronary angiogram. Fractional Flow Reserve (FFR) derived from coronary computed tomographic angiography (FFR-CT) has never been used as a non-invasive t...

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Autores principales: Meier, David, Skalidis, Ioannis, De Bruyne, Bernard, Qanadli, Salah Dine, Rotzinger, David, Eeckhout, Eric, Collet, Carlos, Muller, Olivier, Fournier, Stephane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063126/
https://www.ncbi.nlm.nih.gov/pubmed/32181323
http://dx.doi.org/10.1016/j.ijcha.2020.100496
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author Meier, David
Skalidis, Ioannis
De Bruyne, Bernard
Qanadli, Salah Dine
Rotzinger, David
Eeckhout, Eric
Collet, Carlos
Muller, Olivier
Fournier, Stephane
author_facet Meier, David
Skalidis, Ioannis
De Bruyne, Bernard
Qanadli, Salah Dine
Rotzinger, David
Eeckhout, Eric
Collet, Carlos
Muller, Olivier
Fournier, Stephane
author_sort Meier, David
collection PubMed
description BACKGROUND: In the era of High-sensitive troponin (hs-Tn), up to 50% of patients with a mild increase of hs-Tn will finally have a normal invasive coronary angiogram. Fractional Flow Reserve (FFR) derived from coronary computed tomographic angiography (FFR-CT) has never been used as a non-invasive tool for the diagnosis of coronary artery disease in patients with high-risk acute coronary syndrome without ST segment elevation (NSTE-ACS). AIMS: The study aims to determine the role of coronary CT angiography and FFR-CT in the setting of high-risk NSTE-ACS. METHODOLOGY: We will conduct a prospective trial, enrolling 250 patients admitted with high-risk NSTE-ACS who will rapidly undergo a coronary CT angiography and then a coronary angiography with FFR measurements. Results of coronary CT, FFR-CT and coronary angiography (± FFR) will be compared. POTENTIAL SIGNIFICANCE: In conclusion, non-invasive identification of patients with high-risk NSTE-ACS who could avoid coronary angiography would reduce procedure related risks and medical costs.
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spelling pubmed-70631262020-03-16 Ability of FFR-CT to detect the absence of hemodynamically significant lesions in patients with high-risk NSTE-ACS admitted in the emergency department with chest pain, study design and rationale Meier, David Skalidis, Ioannis De Bruyne, Bernard Qanadli, Salah Dine Rotzinger, David Eeckhout, Eric Collet, Carlos Muller, Olivier Fournier, Stephane Int J Cardiol Heart Vasc Original Paper BACKGROUND: In the era of High-sensitive troponin (hs-Tn), up to 50% of patients with a mild increase of hs-Tn will finally have a normal invasive coronary angiogram. Fractional Flow Reserve (FFR) derived from coronary computed tomographic angiography (FFR-CT) has never been used as a non-invasive tool for the diagnosis of coronary artery disease in patients with high-risk acute coronary syndrome without ST segment elevation (NSTE-ACS). AIMS: The study aims to determine the role of coronary CT angiography and FFR-CT in the setting of high-risk NSTE-ACS. METHODOLOGY: We will conduct a prospective trial, enrolling 250 patients admitted with high-risk NSTE-ACS who will rapidly undergo a coronary CT angiography and then a coronary angiography with FFR measurements. Results of coronary CT, FFR-CT and coronary angiography (± FFR) will be compared. POTENTIAL SIGNIFICANCE: In conclusion, non-invasive identification of patients with high-risk NSTE-ACS who could avoid coronary angiography would reduce procedure related risks and medical costs. Elsevier 2020-03-05 /pmc/articles/PMC7063126/ /pubmed/32181323 http://dx.doi.org/10.1016/j.ijcha.2020.100496 Text en © 2020 The Authors. Published by Elsevier B.V. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Paper
Meier, David
Skalidis, Ioannis
De Bruyne, Bernard
Qanadli, Salah Dine
Rotzinger, David
Eeckhout, Eric
Collet, Carlos
Muller, Olivier
Fournier, Stephane
Ability of FFR-CT to detect the absence of hemodynamically significant lesions in patients with high-risk NSTE-ACS admitted in the emergency department with chest pain, study design and rationale
title Ability of FFR-CT to detect the absence of hemodynamically significant lesions in patients with high-risk NSTE-ACS admitted in the emergency department with chest pain, study design and rationale
title_full Ability of FFR-CT to detect the absence of hemodynamically significant lesions in patients with high-risk NSTE-ACS admitted in the emergency department with chest pain, study design and rationale
title_fullStr Ability of FFR-CT to detect the absence of hemodynamically significant lesions in patients with high-risk NSTE-ACS admitted in the emergency department with chest pain, study design and rationale
title_full_unstemmed Ability of FFR-CT to detect the absence of hemodynamically significant lesions in patients with high-risk NSTE-ACS admitted in the emergency department with chest pain, study design and rationale
title_short Ability of FFR-CT to detect the absence of hemodynamically significant lesions in patients with high-risk NSTE-ACS admitted in the emergency department with chest pain, study design and rationale
title_sort ability of ffr-ct to detect the absence of hemodynamically significant lesions in patients with high-risk nste-acs admitted in the emergency department with chest pain, study design and rationale
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063126/
https://www.ncbi.nlm.nih.gov/pubmed/32181323
http://dx.doi.org/10.1016/j.ijcha.2020.100496
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