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Inhibition of Cholesterol Esterification Enzyme Enhances the Potency of Human Chimeric Antigen Receptor T Cells against Pancreatic Carcinoma

This study aimed to assess the effectiveness of inhibiting cholesterol acyltransferase 1 (ACAT-1) in chimeric antigen receptor T (CAR-T) cells on potentiating the antitumor response against mesothelin (MSLN)-expressing pancreatic carcinoma (PC) cells. We engineered ACAT-1-inhibited CAR-T cells (CAR-...

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Detalles Bibliográficos
Autores principales:	Zhao, Lei, Liu, Yang, Zhao, Fuya, Jin, Ye, Feng, Jing, Geng, Rui, Sun, Jiayu, Kang, Liqing, Yu, Lei, Wei, Yunwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063140/ https://www.ncbi.nlm.nih.gov/pubmed/32181327 http://dx.doi.org/10.1016/j.omto.2020.01.008

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