Cargando…

Granzyme B Attenuates Bacterial Virulence by Targeting Secreted Factors

Pathogenic bacteria secrete virulence factors that interact with the human host to establish infections. The human immune system evolved multiple mechanisms to fight bacterial invaders, including immune proteases that were demonstrated to contribute crucially to antibacterial defense. Here we show t...

Descripción completa

Detalles Bibliográficos
Autores principales:	León, Diego López, Matthey, Patricia, Fellay, Isabelle, Blanchard, Marianne, Martinvalet, Denis, Mantel, Pierre-Yves, Filgueira, Luis, Walch, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063247/ https://www.ncbi.nlm.nih.gov/pubmed/32151975 http://dx.doi.org/10.1016/j.isci.2020.100932

Ejemplares similares

Oxidative and Non-Oxidative Antimicrobial Activities of the Granzymes
por: Lavergne, Marilyne, et al.
Publicado: (2021)

ROS signaling during granzyme B-mediated apoptosis
por: Martinvalet, Denis
Publicado: (2015)

Mitochondrial Entry of Cytotoxic Proteases: A New Insight into the Granzyme B Cell Death Pathway
por: Martinvalet, Denis
Publicado: (2019)

Perforin pores in the endosomal membrane trigger release of endocytosed granzyme B to the cytosol of target cells
por: Thiery, Jerome, et al.
Publicado: (2011)

Improved Purification of Human Granzyme A/B and Granulysin Using a Mammalian Expression System
por: Rasi, Valerio, et al.
Publicado: (2022)

Human Microglia Respond to Malaria-Induced Extracellular Vesicles
por: Mbagwu, Smart Ikechukwu, et al.
Publicado: (2019)

Editorial: The Role of Reactive Oxygen Species in Protective Immunity
por: Martinvalet, Denis, et al.
Publicado: (2022)

Reactive Oxygen Species: Do They Play a Role in Adaptive Immunity?
por: Bassoy, Esen Yonca, et al.
Publicado: (2021)

Validation of Effective Extracellular Vesicles Isolation Methods Adapted to Field Studies in Malaria Endemic Regions
por: Zoia, Matteo, et al.
Publicado: (2022)

A Profound Membrane Reorganization Defines Susceptibility of Plasmodium falciparum Infected Red Blood Cells to Lysis by Granulysin and Perforin
por: Hernández-Castañeda, Maria Andrea, et al.
Publicado: (2021)

Granzyme-A deficiency attenuates experimental osteoarthritis in mice, but perforin deficiency does not
por: Calvo, Jorge, et al.
Publicado: (2023)

MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets
por: Kurioka, A, et al.
Publicado: (2015)

Mast cells decrease efficacy of anti-angiogenic therapy by secreting matrix-degrading granzyme B
por: Wroblewski, M., et al.
Publicado: (2017)

Granzymes—Their Role in Colorectal Cancer
por: Pączek, Sara, et al.
Publicado: (2022)

The role of the mitochondria and the endoplasmic reticulum contact sites in the development of the immune responses
por: Martinvalet, Denis
Publicado: (2018)

Granzyme A in Chikungunya and Other Arboviral Infections
por: Schanoski, Alessandra S., et al.
Publicado: (2020)

Immunotherapeutic Targeting of Membrane Hsp70-Expressing Tumors Using Recombinant Human Granzyme B
por: Gehrmann, Mathias, et al.
Publicado: (2012)

Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis
por: Pardo, Julián, et al.
Publicado: (2004)

Trichosanthin Promotes Anti-Tumor Immunity through Mediating Chemokines and Granzyme B Secretion in Hepatocellular Carcinoma
por: Wang, Kaifang, et al.
Publicado: (2023)

Malaria infected red blood cells release small regulatory RNAs through extracellular vesicles
por: Babatunde, Kehinde Adebayo, et al.
Publicado: (2018)

In silico prediction of the granzyme B degradome
por: Wee, Lawrence JK, et al.
Publicado: (2011)

Modulation of Inflammation by Extracellular Granzyme A
por: van Daalen, Kim R., et al.
Publicado: (2020)

Intracellular and Extracellular Roles of Granzyme K
por: Bouwman, Annemieke C., et al.
Publicado: (2021)

Granzyme B in Autoimmune Skin Disease
por: Gleave, Anna, et al.
Publicado: (2023)

Initiation of Apoptosis by Granzyme B Requires Direct Cleavage of Bid, but Not Direct Granzyme B–Mediated Caspase Activation
por: Sutton, Vivien R., et al.
Publicado: (2000)

Identification and annotation of bovine granzyme genes reveals a novel granzyme encoded within the trypsin-like locus
por: Yang, Jie, et al.
Publicado: (2018)

T3SEdb: data warehousing of virulence effectors secreted by the bacterial Type III Secretion System
por: Tay, Daniel Ming Ming, et al.
Publicado: (2010)

Attenuation of Streptococcus suis virulence by the alteration of bacterial surface architecture
por: Feng, Youjun, et al.
Publicado: (2012)

Molecular mechanisms of bacterial virulence: type III secretion and pathogenicity islands.
por: Mecsas, J J, et al.
Publicado: (1996)

Prediction of T Cell Epitopes from Leishmania major Potentially Excreted/Secreted Proteins Inducing Granzyme B Production
por: Naouar, Ikbel, et al.
Publicado: (2016)

Fish Granzyme A Shows a Greater Role Than Granzyme B in Fish Innate Cell-Mediated Cytotoxicity
por: Chaves-Pozo, Elena, et al.
Publicado: (2019)

Granzymes are necessary for suppressive function of regulatory T cells
por: Co, Dominic O, et al.
Publicado: (2012)

A novel proinflammatory role for granzyme A
por: van Eck, Jacqueline A, et al.
Publicado: (2017)

Granzymes: The Molecular Executors of Immune-Mediated Cytotoxicity
por: Hay, Zachary L. Z., et al.
Publicado: (2022)

Why do human B cells secrete granzyme B? Insights into a novel B-cell differentiation pathway
por: Hagn, Magdalena, et al.
Publicado: (2012)

Site-specific acylation of a bacterial virulence regulator attenuates infection
por: Zhang, Zhenrun J., et al.
Publicado: (2019)

Small Molecule Attenuates Bacterial Virulence by Targeting Conserved Response Regulator
por: Liu, Chang, et al.
Publicado: (2023)

Type IV secretion systems: tools of bacterial horizontal gene transfer and virulence
por: Juhas, Mario, et al.
Publicado: (2008)

Revealing the mechanisms of membrane protein export by virulence-associated bacterial secretion systems
por: Krampen, Lea, et al.
Publicado: (2018)

Modular evolution of secretion systems and virulence plasmids in a bacterial species complex
por: Chou, Lin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_7hak9li4ssog8c03eun406mj0f