High-Throughput Small Molecule Screen Identifies Modulators of Mitochondrial Function in Neurons

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We developed a high-throughput assay for modulators of mitochondrial function in neurons measuring inner mitochondrial membrane potential (ΔΨ(m)) and ATP production. The assay was used to screen a library of small molecules, which led to the identification of structural/functional classes of mitocho...

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Detalles Bibliográficos
Autores principales: Varkuti, Boglarka H., Liu, Ze, Kepiro, Miklos, Pacifico, Rodrigo, Gai, Yunchao, Kameneka, Ted, Davis, Ronald L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063260/
https://www.ncbi.nlm.nih.gov/pubmed/32146326
http://dx.doi.org/10.1016/j.isci.2020.100931
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