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In vitro degradation of pure magnesium―the synergetic influences of glucose and albumin

The biocorrosion of magnesium in the external physiological environment is still difficult to accurately evaluate the degradation behavior in vivo, particularly, in the microenvironment of the patients with hyperglycemia or diabetes. Thus, we explored the synergistic effects of glucose and protein o...

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Autores principales: Yan, Wei, Lian, Yi-Jie, Zhang, Zhi-Yuan, Zeng, Mei-Qi, Zhang, Zhao-Qi, Yin, Zheng-Zheng, Cui, Lan-Yue, Zeng, Rong-Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063336/
https://www.ncbi.nlm.nih.gov/pubmed/32181417
http://dx.doi.org/10.1016/j.bioactmat.2020.02.015
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author Yan, Wei
Lian, Yi-Jie
Zhang, Zhi-Yuan
Zeng, Mei-Qi
Zhang, Zhao-Qi
Yin, Zheng-Zheng
Cui, Lan-Yue
Zeng, Rong-Chang
author_facet Yan, Wei
Lian, Yi-Jie
Zhang, Zhi-Yuan
Zeng, Mei-Qi
Zhang, Zhao-Qi
Yin, Zheng-Zheng
Cui, Lan-Yue
Zeng, Rong-Chang
author_sort Yan, Wei
collection PubMed
description The biocorrosion of magnesium in the external physiological environment is still difficult to accurately evaluate the degradation behavior in vivo, particularly, in the microenvironment of the patients with hyperglycemia or diabetes. Thus, we explored the synergistic effects of glucose and protein on the biodegradation of pure magnesium, so as to have a deeper understanding the mechanism of the degradation in vivo. The surface morphology and corrosion product composition of pure magnesium were investigated using SEM, EDS, FTIR, XRD and XPS. The effect of glucose and albumin on the degradation rate of pure magnesium was investigated via electrochemical and immersion tests. The adsorption of glucose and albumin on the sample surface was observed using fluorescence microscopy. The results showed that the presence of 2 g/L glucose changed the micromorphology of corrosion products on the magnesium surface by reacting with metal cations, thus inhibiting the corrosion of pure magnesium. Protein formed a barrier layer to protect the magnesium at early stage of immersion. The chelation reaction between protein and magnesium surface might accelerate the degradation at later stage. There may be a critical glucose (albumin) content. Biodegradation of pure magnesium was inhibited at low concentrations and promoted at high concentrations. The synergistic effect of glucose and protein restrained the adsorption of aggressive chloride ions to a certain extent, and thus inhibited the degradation of pure magnesium considerably. Moreover, XPS results indicated that glucose promoted the adsorption of protein on the sample surface.
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spelling pubmed-70633362020-03-16 In vitro degradation of pure magnesium―the synergetic influences of glucose and albumin Yan, Wei Lian, Yi-Jie Zhang, Zhi-Yuan Zeng, Mei-Qi Zhang, Zhao-Qi Yin, Zheng-Zheng Cui, Lan-Yue Zeng, Rong-Chang Bioact Mater Article The biocorrosion of magnesium in the external physiological environment is still difficult to accurately evaluate the degradation behavior in vivo, particularly, in the microenvironment of the patients with hyperglycemia or diabetes. Thus, we explored the synergistic effects of glucose and protein on the biodegradation of pure magnesium, so as to have a deeper understanding the mechanism of the degradation in vivo. The surface morphology and corrosion product composition of pure magnesium were investigated using SEM, EDS, FTIR, XRD and XPS. The effect of glucose and albumin on the degradation rate of pure magnesium was investigated via electrochemical and immersion tests. The adsorption of glucose and albumin on the sample surface was observed using fluorescence microscopy. The results showed that the presence of 2 g/L glucose changed the micromorphology of corrosion products on the magnesium surface by reacting with metal cations, thus inhibiting the corrosion of pure magnesium. Protein formed a barrier layer to protect the magnesium at early stage of immersion. The chelation reaction between protein and magnesium surface might accelerate the degradation at later stage. There may be a critical glucose (albumin) content. Biodegradation of pure magnesium was inhibited at low concentrations and promoted at high concentrations. The synergistic effect of glucose and protein restrained the adsorption of aggressive chloride ions to a certain extent, and thus inhibited the degradation of pure magnesium considerably. Moreover, XPS results indicated that glucose promoted the adsorption of protein on the sample surface. KeAi Publishing 2020-03-09 /pmc/articles/PMC7063336/ /pubmed/32181417 http://dx.doi.org/10.1016/j.bioactmat.2020.02.015 Text en © 2020 Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Yan, Wei
Lian, Yi-Jie
Zhang, Zhi-Yuan
Zeng, Mei-Qi
Zhang, Zhao-Qi
Yin, Zheng-Zheng
Cui, Lan-Yue
Zeng, Rong-Chang
In vitro degradation of pure magnesium―the synergetic influences of glucose and albumin
title In vitro degradation of pure magnesium―the synergetic influences of glucose and albumin
title_full In vitro degradation of pure magnesium―the synergetic influences of glucose and albumin
title_fullStr In vitro degradation of pure magnesium―the synergetic influences of glucose and albumin
title_full_unstemmed In vitro degradation of pure magnesium―the synergetic influences of glucose and albumin
title_short In vitro degradation of pure magnesium―the synergetic influences of glucose and albumin
title_sort in vitro degradation of pure magnesium―the synergetic influences of glucose and albumin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063336/
https://www.ncbi.nlm.nih.gov/pubmed/32181417
http://dx.doi.org/10.1016/j.bioactmat.2020.02.015
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