Oncogenic Signaling Alters Cell Shape and Mechanics to Facilitate Cell Division under Confinement

To divide in a tissue, both normal and cancer cells become spherical and mechanically stiffen as they enter mitosis. We investigated the effect of oncogene activation on this process in normal epithelial cells. We found that short-term induction of oncogenic Ras(V12) activates downstream mitogen-act...

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Detalles Bibliográficos
Autores principales: Matthews, Helen K., Ganguli, Sushila, Plak, Katarzyna, Taubenberger, Anna V., Win, Zaw, Williamson, Max, Piel, Matthieu, Guck, Jochen, Baum, Buzz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063569/
https://www.ncbi.nlm.nih.gov/pubmed/32032547
http://dx.doi.org/10.1016/j.devcel.2020.01.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063569/
https://www.ncbi.nlm.nih.gov/pubmed/32032547
http://dx.doi.org/10.1016/j.devcel.2020.01.004

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