Precise and Programmable Detection of Mutations Using Ultraspecific Riboregulators

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The ability to identify single-nucleotide mutations is critical for probing cell biology and for precise detection of disease. However, the small differences in hybridization energy provided by single-base changes makes identification of these mutations challenging in living cells and complex reacti...

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Detalles Bibliográficos
Autores principales: Hong, Fan, Ma, Duo, Wu, Kaiyue, Mina, Lida A., Luiten, Rebecca C., Liu, Yan, Yan, Hao, Green, Alexander A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063572/
https://www.ncbi.nlm.nih.gov/pubmed/32109416
http://dx.doi.org/10.1016/j.cell.2020.02.011
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