NAD(+) Repletion Rescues Female Fertility during Reproductive Aging

Reproductive aging in female mammals is an irreversible process associated with declining oocyte quality, which is the rate-limiting factor to fertility. Here, we show that this loss of oocyte quality with age accompanies declining levels of the prominent metabolic cofactor nicotinamide adenine dinu...

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Detalles Bibliográficos
Autores principales: Bertoldo, Michael J., Listijono, Dave R., Ho, Wing-Hong Jonathan, Riepsamen, Angelique H., Goss, Dale M., Richani, Dulama, Jin, Xing L., Mahbub, Saabah, Campbell, Jared M., Habibalahi, Abbas, Loh, Wei-Guo Nicholas, Youngson, Neil A., Maniam, Jayanthi, Wong, Ashley S.A., Selesniemi, Kaisa, Bustamante, Sonia, Li, Catherine, Zhao, Yiqing, Marinova, Maria B., Kim, Lynn-Jee, Lau, Laurin, Wu, Rachael M., Mikolaizak, A. Stefanie, Araki, Toshiyuki, Le Couteur, David G., Turner, Nigel, Morris, Margaret J., Walters, Kirsty A., Goldys, Ewa, O’Neill, Christopher, Gilchrist, Robert B., Sinclair, David A., Homer, Hayden A., Wu, Lindsay E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063679/
https://www.ncbi.nlm.nih.gov/pubmed/32049001
http://dx.doi.org/10.1016/j.celrep.2020.01.058

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