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Alternative lengthening of telomeres: from molecular mechanisms to therapeutic outlooks
To escape replicative senescence, cancer cells have to overcome telomere attrition during DNA replication. Most of cancers rely on telomerase to extend and maintain telomeres, but 4–11% of cancers use a homologous recombination-based pathway called alternative lengthening of telomeres (ALT). ALT is...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063710/ https://www.ncbi.nlm.nih.gov/pubmed/32175073 http://dx.doi.org/10.1186/s13578-020-00391-6 |