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Recurrent Hypoglycemia in a Case of Congenital Analbuminemia
In congenital analbuminemia (CAA), mutations in the albumin gene result in a severe deficiency or absence of plasma albumin. Only about 90 cases have been reported to date, but the specific features of glucose and lipid metabolism in congenital analbuminemia have only been studied in a rat model of...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063871/ https://www.ncbi.nlm.nih.gov/pubmed/32181025 http://dx.doi.org/10.1155/2020/8452564 |
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author | Litzel, Martin Caridi, Gianluca Lugani, Francesca Campagnoli, Monica Minchiotti, Lorenzo Fischli, Stefan |
author_facet | Litzel, Martin Caridi, Gianluca Lugani, Francesca Campagnoli, Monica Minchiotti, Lorenzo Fischli, Stefan |
author_sort | Litzel, Martin |
collection | PubMed |
description | In congenital analbuminemia (CAA), mutations in the albumin gene result in a severe deficiency or absence of plasma albumin. Only about 90 cases have been reported to date, but the specific features of glucose and lipid metabolism in congenital analbuminemia have only been studied in a rat model of analbuminemia. We report the case of a female patient hospitalized for a streptococcal skin infection who showed recurrent hypoglycemia. A diagnosis of CAA was confirmed by mutation analysis and by the detection of a single base variation in the ALB gene. Hypoglycemia was first documented after a fasting period during acute illness. Recurrent hypoglycemia persisted despite good general condition and normal nutrition during antimicrobial therapy with moxifloxacin. Several contributing factors causing this hypoglycemia can be discussed. Individuals with CAA are prone to adverse drug effects caused by changes in drug-protein binding properties. It is unclear if specific changes of glucose and lipid metabolism in CAA constitute a risk factor for hypoglycemia. |
format | Online Article Text |
id | pubmed-7063871 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-70638712020-03-16 Recurrent Hypoglycemia in a Case of Congenital Analbuminemia Litzel, Martin Caridi, Gianluca Lugani, Francesca Campagnoli, Monica Minchiotti, Lorenzo Fischli, Stefan Case Rep Endocrinol Case Report In congenital analbuminemia (CAA), mutations in the albumin gene result in a severe deficiency or absence of plasma albumin. Only about 90 cases have been reported to date, but the specific features of glucose and lipid metabolism in congenital analbuminemia have only been studied in a rat model of analbuminemia. We report the case of a female patient hospitalized for a streptococcal skin infection who showed recurrent hypoglycemia. A diagnosis of CAA was confirmed by mutation analysis and by the detection of a single base variation in the ALB gene. Hypoglycemia was first documented after a fasting period during acute illness. Recurrent hypoglycemia persisted despite good general condition and normal nutrition during antimicrobial therapy with moxifloxacin. Several contributing factors causing this hypoglycemia can be discussed. Individuals with CAA are prone to adverse drug effects caused by changes in drug-protein binding properties. It is unclear if specific changes of glucose and lipid metabolism in CAA constitute a risk factor for hypoglycemia. Hindawi 2020-02-27 /pmc/articles/PMC7063871/ /pubmed/32181025 http://dx.doi.org/10.1155/2020/8452564 Text en Copyright © 2020 Martin Litzel et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Litzel, Martin Caridi, Gianluca Lugani, Francesca Campagnoli, Monica Minchiotti, Lorenzo Fischli, Stefan Recurrent Hypoglycemia in a Case of Congenital Analbuminemia |
title | Recurrent Hypoglycemia in a Case of Congenital Analbuminemia |
title_full | Recurrent Hypoglycemia in a Case of Congenital Analbuminemia |
title_fullStr | Recurrent Hypoglycemia in a Case of Congenital Analbuminemia |
title_full_unstemmed | Recurrent Hypoglycemia in a Case of Congenital Analbuminemia |
title_short | Recurrent Hypoglycemia in a Case of Congenital Analbuminemia |
title_sort | recurrent hypoglycemia in a case of congenital analbuminemia |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063871/ https://www.ncbi.nlm.nih.gov/pubmed/32181025 http://dx.doi.org/10.1155/2020/8452564 |
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