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Consensus guidelines for the definition, detection and interpretation of immunogenic cell death
Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenvironmental features determine the propensity of RCD t...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BMJ Publishing Group
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064135/ https://www.ncbi.nlm.nih.gov/pubmed/32209603 http://dx.doi.org/10.1136/jitc-2019-000337 |
| _version_ | 1783504824030986240 |
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| author | Galluzzi, Lorenzo Vitale, Ilio Warren, Sarah Adjemian, Sandy Agostinis, Patrizia Martinez, Aitziber Buqué Chan, Timothy A Coukos, George Demaria, Sandra Deutsch, Eric Draganov, Dobrin Edelson, Richard L Formenti, Silvia C Fucikova, Jitka Gabriele, Lucia Gaipl, Udo S Gameiro, Sofia R Garg, Abhishek D Golden, Encouse Han, Jian Harrington, Kevin J Hemminki, Akseli Hodge, James W Hossain, Dewan Md Sakib Illidge, Tim Karin, Michael Kaufman, Howard L Kepp, Oliver Kroemer, Guido Lasarte, Juan Jose Loi, Sherene Lotze, Michael T Manic, Gwenola Merghoub, Taha Melcher, Alan A Mossman, Karen L Prosper, Felipe Rekdal, Øystein Rescigno, Maria Riganti, Chiara Sistigu, Antonella Smyth, Mark J Spisek, Radek Stagg, John Strauss, Bryan E Tang, Daolin Tatsuno, Kazuki van Gool, Stefaan W Vandenabeele, Peter Yamazaki, Takahiro Zamarin, Dmitriy Zitvogel, Laurence Cesano, Alessandra Marincola, Francesco M |
| author_facet | Galluzzi, Lorenzo Vitale, Ilio Warren, Sarah Adjemian, Sandy Agostinis, Patrizia Martinez, Aitziber Buqué Chan, Timothy A Coukos, George Demaria, Sandra Deutsch, Eric Draganov, Dobrin Edelson, Richard L Formenti, Silvia C Fucikova, Jitka Gabriele, Lucia Gaipl, Udo S Gameiro, Sofia R Garg, Abhishek D Golden, Encouse Han, Jian Harrington, Kevin J Hemminki, Akseli Hodge, James W Hossain, Dewan Md Sakib Illidge, Tim Karin, Michael Kaufman, Howard L Kepp, Oliver Kroemer, Guido Lasarte, Juan Jose Loi, Sherene Lotze, Michael T Manic, Gwenola Merghoub, Taha Melcher, Alan A Mossman, Karen L Prosper, Felipe Rekdal, Øystein Rescigno, Maria Riganti, Chiara Sistigu, Antonella Smyth, Mark J Spisek, Radek Stagg, John Strauss, Bryan E Tang, Daolin Tatsuno, Kazuki van Gool, Stefaan W Vandenabeele, Peter Yamazaki, Takahiro Zamarin, Dmitriy Zitvogel, Laurence Cesano, Alessandra Marincola, Francesco M |
| author_sort | Galluzzi, Lorenzo |
| collection | PubMed |
| description | Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenvironmental features determine the propensity of RCD to drive adaptive immunity. Here, we provide an updated operational definition of immunogenic cell death (ICD), discuss the key factors that dictate the ability of dying cells to drive an adaptive immune response, summarize experimental assays that are currently available for the assessment of ICD in vitro and in vivo, and formulate guidelines for their interpretation. |
| format | Online Article Text |
| id | pubmed-7064135 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | BMJ Publishing Group |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-70641352020-03-20 Consensus guidelines for the definition, detection and interpretation of immunogenic cell death Galluzzi, Lorenzo Vitale, Ilio Warren, Sarah Adjemian, Sandy Agostinis, Patrizia Martinez, Aitziber Buqué Chan, Timothy A Coukos, George Demaria, Sandra Deutsch, Eric Draganov, Dobrin Edelson, Richard L Formenti, Silvia C Fucikova, Jitka Gabriele, Lucia Gaipl, Udo S Gameiro, Sofia R Garg, Abhishek D Golden, Encouse Han, Jian Harrington, Kevin J Hemminki, Akseli Hodge, James W Hossain, Dewan Md Sakib Illidge, Tim Karin, Michael Kaufman, Howard L Kepp, Oliver Kroemer, Guido Lasarte, Juan Jose Loi, Sherene Lotze, Michael T Manic, Gwenola Merghoub, Taha Melcher, Alan A Mossman, Karen L Prosper, Felipe Rekdal, Øystein Rescigno, Maria Riganti, Chiara Sistigu, Antonella Smyth, Mark J Spisek, Radek Stagg, John Strauss, Bryan E Tang, Daolin Tatsuno, Kazuki van Gool, Stefaan W Vandenabeele, Peter Yamazaki, Takahiro Zamarin, Dmitriy Zitvogel, Laurence Cesano, Alessandra Marincola, Francesco M J Immunother Cancer Review Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenvironmental features determine the propensity of RCD to drive adaptive immunity. Here, we provide an updated operational definition of immunogenic cell death (ICD), discuss the key factors that dictate the ability of dying cells to drive an adaptive immune response, summarize experimental assays that are currently available for the assessment of ICD in vitro and in vivo, and formulate guidelines for their interpretation. BMJ Publishing Group 2020-03-09 /pmc/articles/PMC7064135/ /pubmed/32209603 http://dx.doi.org/10.1136/jitc-2019-000337 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Review Galluzzi, Lorenzo Vitale, Ilio Warren, Sarah Adjemian, Sandy Agostinis, Patrizia Martinez, Aitziber Buqué Chan, Timothy A Coukos, George Demaria, Sandra Deutsch, Eric Draganov, Dobrin Edelson, Richard L Formenti, Silvia C Fucikova, Jitka Gabriele, Lucia Gaipl, Udo S Gameiro, Sofia R Garg, Abhishek D Golden, Encouse Han, Jian Harrington, Kevin J Hemminki, Akseli Hodge, James W Hossain, Dewan Md Sakib Illidge, Tim Karin, Michael Kaufman, Howard L Kepp, Oliver Kroemer, Guido Lasarte, Juan Jose Loi, Sherene Lotze, Michael T Manic, Gwenola Merghoub, Taha Melcher, Alan A Mossman, Karen L Prosper, Felipe Rekdal, Øystein Rescigno, Maria Riganti, Chiara Sistigu, Antonella Smyth, Mark J Spisek, Radek Stagg, John Strauss, Bryan E Tang, Daolin Tatsuno, Kazuki van Gool, Stefaan W Vandenabeele, Peter Yamazaki, Takahiro Zamarin, Dmitriy Zitvogel, Laurence Cesano, Alessandra Marincola, Francesco M Consensus guidelines for the definition, detection and interpretation of immunogenic cell death |
| title | Consensus guidelines for the definition, detection and interpretation of immunogenic cell death |
| title_full | Consensus guidelines for the definition, detection and interpretation of immunogenic cell death |
| title_fullStr | Consensus guidelines for the definition, detection and interpretation of immunogenic cell death |
| title_full_unstemmed | Consensus guidelines for the definition, detection and interpretation of immunogenic cell death |
| title_short | Consensus guidelines for the definition, detection and interpretation of immunogenic cell death |
| title_sort | consensus guidelines for the definition, detection and interpretation of immunogenic cell death |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064135/ https://www.ncbi.nlm.nih.gov/pubmed/32209603 http://dx.doi.org/10.1136/jitc-2019-000337 |
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