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Brain Shuttle Neprilysin reduces central Amyloid-β levels

Reducing Amyloid β (Aβ) in the brain is of fundamental importance for advancing the therapeutics for Alzheimer`s disease. The endogenous metallopeptidase neprilysin (NEP) has been identified as one of the key Aβ-degrading enzymes. Delivery of NEP to the brain by utilizing the Brain Shuttle (BS) tran...

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Detalles Bibliográficos
Autores principales:	Campos, Christopher R., Kemble, Alicia M., Niewoehner, Jens, Freskgård, Per-Ola, Urich, Eduard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064168/ https://www.ncbi.nlm.nih.gov/pubmed/32155191 http://dx.doi.org/10.1371/journal.pone.0229850

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