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Functional analysis of proposed substrate-binding residues of Hsp104

Hsp104 is a hexameric AAA+ yeast disaggregase capable of solubilizing disordered aggregates and amyloid. Hsp104 couples ATP hydrolysis to polypeptide translocation through its central channel. Substrate binding by Hsp104 is mediated primarily by two conserved tyrosine residues in nucleotide binding...

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Detalles Bibliográficos
Autores principales:	Howard, Matthew K., Sohn, Brian S., von Borcke, Julius, Xu, Andy, Jackrel, Meredith E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064214/ https://www.ncbi.nlm.nih.gov/pubmed/32155221 http://dx.doi.org/10.1371/journal.pone.0230198

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