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Resegmentation is an ancestral feature of the gnathostome vertebral skeleton

The vertebral skeleton is a defining feature of vertebrate animals. However, the mode of vertebral segmentation varies considerably between major lineages. In tetrapods, adjacent somite halves recombine to form a single vertebra through the process of ‘resegmentation’. In teleost fishes, there is co...

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Autores principales: Criswell, Katharine E, Gillis, J Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064331/
https://www.ncbi.nlm.nih.gov/pubmed/32091389
http://dx.doi.org/10.7554/eLife.51696
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author Criswell, Katharine E
Gillis, J Andrew
author_facet Criswell, Katharine E
Gillis, J Andrew
author_sort Criswell, Katharine E
collection PubMed
description The vertebral skeleton is a defining feature of vertebrate animals. However, the mode of vertebral segmentation varies considerably between major lineages. In tetrapods, adjacent somite halves recombine to form a single vertebra through the process of ‘resegmentation’. In teleost fishes, there is considerable mixing between cells of the anterior and posterior somite halves, without clear resegmentation. To determine whether resegmentation is a tetrapod novelty, or an ancestral feature of jawed vertebrates, we tested the relationship between somites and vertebrae in a cartilaginous fish, the skate (Leucoraja erinacea). Using cell lineage tracing, we show that skate trunk vertebrae arise through tetrapod-like resegmentation, with anterior and posterior halves of each vertebra deriving from adjacent somites. We further show that tail vertebrae also arise through resegmentation, though with a duplication of the number of vertebrae per body segment. These findings resolve axial resegmentation as an ancestral feature of the jawed vertebrate body plan.
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spelling pubmed-70643312020-03-11 Resegmentation is an ancestral feature of the gnathostome vertebral skeleton Criswell, Katharine E Gillis, J Andrew eLife Developmental Biology The vertebral skeleton is a defining feature of vertebrate animals. However, the mode of vertebral segmentation varies considerably between major lineages. In tetrapods, adjacent somite halves recombine to form a single vertebra through the process of ‘resegmentation’. In teleost fishes, there is considerable mixing between cells of the anterior and posterior somite halves, without clear resegmentation. To determine whether resegmentation is a tetrapod novelty, or an ancestral feature of jawed vertebrates, we tested the relationship between somites and vertebrae in a cartilaginous fish, the skate (Leucoraja erinacea). Using cell lineage tracing, we show that skate trunk vertebrae arise through tetrapod-like resegmentation, with anterior and posterior halves of each vertebra deriving from adjacent somites. We further show that tail vertebrae also arise through resegmentation, though with a duplication of the number of vertebrae per body segment. These findings resolve axial resegmentation as an ancestral feature of the jawed vertebrate body plan. eLife Sciences Publications, Ltd 2020-02-24 /pmc/articles/PMC7064331/ /pubmed/32091389 http://dx.doi.org/10.7554/eLife.51696 Text en © 2020, Criswell and Gillis http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Developmental Biology
Criswell, Katharine E
Gillis, J Andrew
Resegmentation is an ancestral feature of the gnathostome vertebral skeleton
title Resegmentation is an ancestral feature of the gnathostome vertebral skeleton
title_full Resegmentation is an ancestral feature of the gnathostome vertebral skeleton
title_fullStr Resegmentation is an ancestral feature of the gnathostome vertebral skeleton
title_full_unstemmed Resegmentation is an ancestral feature of the gnathostome vertebral skeleton
title_short Resegmentation is an ancestral feature of the gnathostome vertebral skeleton
title_sort resegmentation is an ancestral feature of the gnathostome vertebral skeleton
topic Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064331/
https://www.ncbi.nlm.nih.gov/pubmed/32091389
http://dx.doi.org/10.7554/eLife.51696
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