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Resegmentation is an ancestral feature of the gnathostome vertebral skeleton
The vertebral skeleton is a defining feature of vertebrate animals. However, the mode of vertebral segmentation varies considerably between major lineages. In tetrapods, adjacent somite halves recombine to form a single vertebra through the process of ‘resegmentation’. In teleost fishes, there is co...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064331/ https://www.ncbi.nlm.nih.gov/pubmed/32091389 http://dx.doi.org/10.7554/eLife.51696 |
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author | Criswell, Katharine E Gillis, J Andrew |
author_facet | Criswell, Katharine E Gillis, J Andrew |
author_sort | Criswell, Katharine E |
collection | PubMed |
description | The vertebral skeleton is a defining feature of vertebrate animals. However, the mode of vertebral segmentation varies considerably between major lineages. In tetrapods, adjacent somite halves recombine to form a single vertebra through the process of ‘resegmentation’. In teleost fishes, there is considerable mixing between cells of the anterior and posterior somite halves, without clear resegmentation. To determine whether resegmentation is a tetrapod novelty, or an ancestral feature of jawed vertebrates, we tested the relationship between somites and vertebrae in a cartilaginous fish, the skate (Leucoraja erinacea). Using cell lineage tracing, we show that skate trunk vertebrae arise through tetrapod-like resegmentation, with anterior and posterior halves of each vertebra deriving from adjacent somites. We further show that tail vertebrae also arise through resegmentation, though with a duplication of the number of vertebrae per body segment. These findings resolve axial resegmentation as an ancestral feature of the jawed vertebrate body plan. |
format | Online Article Text |
id | pubmed-7064331 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-70643312020-03-11 Resegmentation is an ancestral feature of the gnathostome vertebral skeleton Criswell, Katharine E Gillis, J Andrew eLife Developmental Biology The vertebral skeleton is a defining feature of vertebrate animals. However, the mode of vertebral segmentation varies considerably between major lineages. In tetrapods, adjacent somite halves recombine to form a single vertebra through the process of ‘resegmentation’. In teleost fishes, there is considerable mixing between cells of the anterior and posterior somite halves, without clear resegmentation. To determine whether resegmentation is a tetrapod novelty, or an ancestral feature of jawed vertebrates, we tested the relationship between somites and vertebrae in a cartilaginous fish, the skate (Leucoraja erinacea). Using cell lineage tracing, we show that skate trunk vertebrae arise through tetrapod-like resegmentation, with anterior and posterior halves of each vertebra deriving from adjacent somites. We further show that tail vertebrae also arise through resegmentation, though with a duplication of the number of vertebrae per body segment. These findings resolve axial resegmentation as an ancestral feature of the jawed vertebrate body plan. eLife Sciences Publications, Ltd 2020-02-24 /pmc/articles/PMC7064331/ /pubmed/32091389 http://dx.doi.org/10.7554/eLife.51696 Text en © 2020, Criswell and Gillis http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Developmental Biology Criswell, Katharine E Gillis, J Andrew Resegmentation is an ancestral feature of the gnathostome vertebral skeleton |
title | Resegmentation is an ancestral feature of the gnathostome vertebral skeleton |
title_full | Resegmentation is an ancestral feature of the gnathostome vertebral skeleton |
title_fullStr | Resegmentation is an ancestral feature of the gnathostome vertebral skeleton |
title_full_unstemmed | Resegmentation is an ancestral feature of the gnathostome vertebral skeleton |
title_short | Resegmentation is an ancestral feature of the gnathostome vertebral skeleton |
title_sort | resegmentation is an ancestral feature of the gnathostome vertebral skeleton |
topic | Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064331/ https://www.ncbi.nlm.nih.gov/pubmed/32091389 http://dx.doi.org/10.7554/eLife.51696 |
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