Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing

Mammalian circadian rhythms are generated by a transcription-based feedback loop in which CLOCK:BMAL1 drives transcription of its repressors (PER1/2, CRY1/2), which ultimately interact with CLOCK:BMAL1 to close the feedback loop with ~24 hr periodicity. Here we pinpoint a key difference between CRY1...

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Detalles Bibliográficos
Autores principales: Fribourgh, Jennifer L, Srivastava, Ashutosh, Sandate, Colby R, Michael, Alicia K, Hsu, Peter L, Rakers, Christin, Nguyen, Leslee T, Torgrimson, Megan R, Parico, Gian Carlo G, Tripathi, Sarvind, Zheng, Ning, Lander, Gabriel C, Hirota, Tsuyoshi, Tama, Florence, Partch, Carrie L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064333/
https://www.ncbi.nlm.nih.gov/pubmed/32101164
http://dx.doi.org/10.7554/eLife.55275

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