Transient DNMT3L Expression Reinforces Chromatin Surveillance to Halt Senescence Progression in Mouse Embryonic Fibroblast

Global heterochromatin reduction, which is one of the hallmarks of senescent cells, is associated with reduced transposable element repression and increased risk of chromatin instability. To ensure genomic integrity, the irreparable cells in a population exit permanently from the cell cycle, and thi...

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Detalles Bibliográficos
Autores principales: Yu, Yoyo Chih-Yun, Hui, Tony ZK, Kao, Tzu-Hao, Liao, Hung-Fu, Yang, Chih-Yi, Hou, Chia-Chun, Hsieh, Hsin-Ting, Chang, Jen-Yun, Tsai, Yi-Tzang, Pinskaya, Marina, Yang, Kai-Chien, Chen, Yet-Ran, Morillon, Antonin, Tsai, Mong-Hsun, Lin, Shau-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064442/
https://www.ncbi.nlm.nih.gov/pubmed/32195249
http://dx.doi.org/10.3389/fcell.2020.00103

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